Relationship Between Difference of Preoperative and Cardiopulmonary Bypass Mean Arterial Pressure, and Acute Kidney Injury in Cardiac Surgical Patients Undergoing Valve Surgery

January 8, 2024 No Comments

In a study of 112 high-risk cardiac surgery patients, it was found that the difference in pre-operative and on-bypass mean arterial pressure (MAP) and cardiopulmonary bypass (CPB) flows did not significantly predict early post-surgical acute kidney injury (CSA-AKI). However, baseline serum levels of Neutrophil gelatinase-associated lipocalin (NGAL) and its early post-surgical percent change were strong independent predictors of CSA-AKI development, suggesting its potential as a useful biomarker in identifying patients at risk.

Hemolysis Precedes Urine Color Change in Patients Undergoing Open-Heart Surgery on Cardiopulmonary Bypass

January 5, 2024 No Comments

This study investigated the relationship between plasma free hemoglobin levels and changes in urine color in cardiac surgery patients undergoing cardiopulmonary bypass. It found that changes in urine color or increases in urinary free hemoglobin occurred considerably later than elevations in plasma free hemoglobin levels.

Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery

December 26, 2023 No Comments

This study explores urinary collectrin as a potential biomarker for early detection of acute kidney injury (AKI) in patients undergoing cardiac surgery with cardiopulmonary bypass. It found significant perioperative changes in collectrin levels, particularly on postoperative day 1, indicating its promise for timely AKI diagnosis and intervention, though further research is needed for clinical validation.

Incorporating Intraoperative Blood Pressure Time-Series Variables to Assist in Prediction of Acute Kidney Injury After Type A Acute Aortic Dissection Repair: An Interpretable Machine Learning Model

December 25, 2023 No Comments

This study developed an XGBoost machine learning model using intraoperative blood pressure time-series data to predict the risk of acute kidney injury (AKI) after Type A acute aortic dissection repair. The model, which outperformed others in accuracy, identified factors like intraoperative urine output and the duration of mean arterial pressure below 65 mmHg as critical predictors for postoperative AKI.

Meropenem Extraction by Ex Vivo Extracorporeal Life Support Circuits

December 22, 2023 No Comments

The study investigates the impact of ECMO and CRRT circuits on meropenem pharmacokinetics, finding minimal extraction by ECMO components but rapid clearance during CRRT, indicating a need for adjusted meropenem dosing in critically ill patients on these therapies. Meropenem underwent significant degradation/metabolism in physiological conditions, informing clinicians on dosing strategies.

Alterations to Kidney Physiology during Cardiopulmonary Bypass-A Narrative Review of the Literature and Practical Remarks

December 1, 2023 No Comments

Considering the available scientific evidence, it is concluded that adequate kidney perfusion and fluid balance are the most critical factors determining postoperative kidney function.