International Perfusion Association
This study investigated the relationship between plasma free hemoglobin levels and changes in urine color in cardiac surgery patients undergoing cardiopulmonary bypass. It found that changes in urine color or increases in urinary free hemoglobin occurred considerably later than elevations in plasma free hemoglobin levels.
This study explores urinary collectrin as a potential biomarker for early detection of acute kidney injury (AKI) in patients undergoing cardiac surgery with cardiopulmonary bypass. It found significant perioperative changes in collectrin levels, particularly on postoperative day 1, indicating its promise for timely AKI diagnosis and intervention, though further research is needed for clinical validation.
This study developed an XGBoost machine learning model using intraoperative blood pressure time-series data to predict the risk of acute kidney injury (AKI) after Type A acute aortic dissection repair. The model, which outperformed others in accuracy, identified factors like intraoperative urine output and the duration of mean arterial pressure below 65 mmHg as critical predictors for postoperative AKI.
The study investigates the impact of ECMO and CRRT circuits on meropenem pharmacokinetics, finding minimal extraction by ECMO components but rapid clearance during CRRT, indicating a need for adjusted meropenem dosing in critically ill patients on these therapies. Meropenem underwent significant degradation/metabolism in physiological conditions, informing clinicians on dosing strategies.
Considering the available scientific evidence, it is concluded that adequate kidney perfusion and fluid balance are the most critical factors determining postoperative kidney function.
