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ECMO Under Pressure

The Invisible Face of ECMO: Anxiety Levels and Challenges Among Intensive Care Nurses

This cross-sectional study examined 137 ICU nurses in Turkey who cared for patients receiving ECMO, a complex life-support therapy. Nurses reported mild-to-moderate anxiety, with higher stress linked to bleeding risk, infection concerns, workload, complications, and team-related organizational problems. More ECMO-specific experience was associated with lower anxiety, highlighting the value of structured training, standardized protocols, and experienced staffing.

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April 12, 2026
Perfusion Under Pressure

Elevated Oxygen Extraction During Heart Transplantation Is Associated With Increased Morbidity and Mortality: Implications for Goal-Directed Perfusion

This single-center retrospective study of 381 adult heart transplants found that prolonged oxygen extraction ratio, or O2ER, above 0.20 during cardiopulmonary bypass was linked to higher post-transplant morbidity and early mortality. O2ER outperformed low indexed oxygen delivery alone in predicting risk, especially around reperfusion, suggesting that perfusion strategies should focus on matching oxygen delivery to metabolic demand rather than relying only on fixed delivery thresholds.

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April 12, 2026
Triple Transplant Breakthrough

Heart-Liver-Kidney Transplantation for AL Amyloidosis Using Normothermic Recovery and Storage From a Donor Following Circulatory Death: Short-Term Outcome in a First-in-World Experience

This case report describes the first known heart-liver-kidney transplant for AL amyloidosis using organs recovered from a donation-after-circulatory-death donor with thoracoabdominal normothermic regional perfusion. A 40-year-old man with terminal multiorgan AL amyloidosis underwent sequential heart, liver, and kidney transplantation and remained free of graft dysfunction or rejection at 8 months, highlighting a new path to expand complex transplant access. 

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April 8, 2026
Kidney on Call

Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury Requiring Dialysis After Cardiac Surgery: A Retrospective Study from the National Heart Institute of Malaysia

This retrospective Malaysian cohort study examined 6,779 adult cardiac surgery patients and found that 4.5% developed postoperative acute kidney injury requiring dialysis. Risk was higher in patients with chronic kidney disease, urgent surgery, diabetes, reoperation, and longer ICU stay. Dialysis-requiring AKI was linked to sharply increased mortality, especially among patients without baseline CKD, highlighting the need for earlier renal risk stratification and kidney-protective perioperative care.

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April 6, 2026
The Combined Use of HA380 Hemoperfusion

The Combined Use of HA380 Hemoperfusion in Cardiopulmonary Bypass Alleviates Postoperative Inflammatory Response and Organ Dysfunction Following Cardiac Surgery

This randomized single-center trial evaluated 65 patients undergoing elective cardiac surgery with cardiopulmonary bypass and found that adding the HA380 hemoperfusion cartridge reduced early postoperative inflammatory cytokines, including IL-1β, IL-6, IL-8, and IL-10. The HA380 group also had lower vasoactive-inotropic requirements and better short-term liver and kidney laboratory markers, although ICU ventilation time and ICU stay were not significantly improved. 

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April 6, 2026
ECLS Lab Standards

Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development

This guideline article argues that extracorporeal life support device testing should follow standardized in-vitro protocols so results can be reproduced, compared across research groups, and translated more effectively into practice. It outlines reporting criteria, relevant ISO standards, preferred test conditions, and key considerations for pumps, oxygenators, cannulae, tubing, hemolysis, and thrombogenicity assessment.

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April 5, 2026
Transfusion Blood Cardiac Surgery

Quality Management of Comprehensive Blood Conservation Strategies During Cardiopulmonary Bypass in Pediatric Cardiac Surgery

This retrospective single-center study evaluated 9,792 children aged 14 years or younger undergoing cardiac surgery with cardiopulmonary bypass. After implementation of a quality-managed, multimodal blood conservation program, matched analysis showed lower PRBC and plasma transfusion rates, smaller CPB priming volumes, and fewer postoperative complications, especially liver injury and acute kidney injury, without increased mortality or longer recovery.

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April 2, 2026
Bright Operating Room Scene for Normoxic vs Hyperoxic CABG Reperfusion

Normoxic versus Hyperoxic Reperfusion: A Retrospective Study of Ischemia–Reperfusion Injury in Patients Undergoing On-Pump Coronary Artery Bypass Grafting

This retrospective study compared normoxic and hyperoxic reperfusion strategies in 50 patients undergoing elective on-pump CABG. Although oxygen delivery was similar between groups, normoxic management was associated with lower postoperative myocardial injury, better cardiac index, smaller declines in ejection fraction, and lower oxidative stress. The findings suggest that physiology-guided oxygenation may reduce ischemia–reperfusion injury during cardiopulmonary bypass.

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April 1, 2026
The Impact of Re-operation on Aortic Arch Reconstructive Surgery

The Impact of Re-operation on Aortic Arch Reconstructive Surgery: Evidence from a Multicentre, National Registry

This multicenter Canadian registry study examined 2,481 patients who underwent aortic arch reconstruction between 2002 and 2021, including 374 redo cases after prior open-heart surgery. Despite a higher comorbidity burden, redo surgery was not associated with significantly higher overall operative mortality or major morbidity than primary surgery. Risk increased with older age, acute dissection or rupture, and longer cardiopulmonary bypass time.

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April 1, 2026
AI-Driven Cardiac Surgery Future

Artificial Intelligence in Adult Cardiovascular Medicine and Surgery: Real-World Deployments and Outcomes

Artificial intelligence (AI) is transforming adult cardiovascular medicine and surgery by enhancing diagnostics, surgical planning, intraoperative precision, and postoperative monitoring. Tools such as AI-ECG, automated imaging, and predictive analytics improve risk stratification and outcomes. While real-world deployments show promise, challenges including data quality, bias, and limited prospective validation remain barriers to widespread adoption.

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April 1, 2026
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