Ultrafiltration (UF) during cardiopulmonary bypass for cardiac surgery was found to enhance coagulation profiles by increasing clot firmness, as evidenced by significant rises in maximum clot firmness (MCF) in a retrospective study of 75 patients. The effectiveness of UF in improving clot firmness was particularly notable in patients with reduced pre-UF MCF, indicating a potential targeted benefit of UF in managing coagulation during cardiac procedures.