Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

This non-inferiority study evaluates the Quantum Perfusion System (QPS) for continuous blood gas monitoring during cardiopulmonary bypass (CPB) against the standard blood gas analyzer (BGA). Using data from 40 patients undergoing cardiac surgeries, QPS demonstrated high accuracy and agreement with BGA across all key parameters, adhering to Clinical Laboratory Improvement Amendments (CLIA) standards, and validating its utility as a trending device.

April 3, 2025

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

The article explores the safety and effectiveness of the MANTA vascular closure device for managing large-bore arteriotomy, particularly post-decannulation in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients. Findings suggest the MANTA device reduces vascular complications and offers a viable, low-risk option for critically ill patients, though further high-powered studies are needed to confirm superiority over other closure methods.

April 2, 2025

Perioperative Bleeding Is Not an Independent Risk Factor for Acute Kidney Injury in On-pump Cardiac Surgery—A Post-hoc Analysis of a Randomized Clinical Trial

A post-hoc analysis of the ALBICS randomized trial with 1,386 cardiac surgery patients found that perioperative bleeding, as classified by the Universal Definition of Perioperative Bleeding (UDPB), was not independently linked to acute kidney injury (AKI). Rather, bleeding indirectly contributed to AKI through hypotension and fluid overload. The only transfusion product independently associated with AKI was fresh frozen plasma.

April 1, 2025

A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

This study compared six Health Canada-approved cardiopulmonary bypass (CPB) circuits in 872 cardiac surgery patients to assess their effects on bleeding and coagulation. While all circuits impaired coagulation, significant differences in bleeding severity and transfusion requirements were found after adjusting for patient and procedural factors. Circuit 6 showed the best performance in minimizing transfusion needs.

March 30, 2025

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

This study compares two cardioplegic solutions—HTK and Del Nido—for their impact on cerebral inflammation in a porcine cardiopulmonary bypass model. Results showed that while both solutions produced comparable hypoxia and inflammation markers overall, HTK led to more pronounced hyponatremia, hypochloremia, and increased IL-1β mRNA in certain brain regions. Del Nido cardioplegia provided more stable electrolyte levels and less cerebral inflammation.

March 30, 2025

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

This study presents the development of a novel optical CO₂ sensor for use in extracorporeal life support (ECLS) systems such as ECMO and ECCO₂R. The sensor accurately measures CO₂ concentration in oxygenator exhaust gas and gas flow to determine CO₂ removal rates. A built-in heating system prevents condensation, and a temperature control algorithm ensures measurement accuracy. Laboratory and in vivo validations confirm its clinical suitability.

March 30, 2025

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

This retrospective study evaluates the safety and efficacy of innominate artery (IA) graft cannulation for selective antegrade cerebral perfusion (SACP) in aortic surgery. Analyzing 196 patients, including those with Type A acute aortic dissection and Marfan syndrome, the results showed low rates of stroke (2.04%), mortality (3.06%), and acute renal failure (3.06%). IA graft cannulation emerged as a reliable and efficient technique for cerebral protection during complex aortic procedures.

March 29, 2025

CytoSorb Hemoadsorption of Apixaban During Cardio-Pulmonary Bypass for Heart Transplantation

This case study reports on the successful intraoperative removal of apixaban using a CytoSorb hemoadsorption device during emergency heart transplantation. The 61-year-old patient, previously on apixaban, underwent cardiopulmonary bypass (CPB), during which the device significantly reduced anticoagulant levels without complications. The results suggest CytoSorb may offer a viable method to manage DOACs in urgent cardiac surgery settings.

March 29, 2025

Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation During Cardiopulmonary Bypass

This randomized clinical study assessed how varying sweep gas flow rates affect respiratory alkalosis and cerebral oxygenation during cardiopulmonary bypass (CPB) in 84 open-heart surgery patients. The findings revealed that lower sweep gas flow rates help maintain normal carbon dioxide levels and enhance cerebral oxygen saturation post-rewarming. Adjusting the sweep gas flow rate before rewarming may prevent complications associated with respiratory alkalosis.

March 25, 2025

Cardiopulmonary Bypass and Cross-Clamping Times in Aortic Valve Replacement Surgery by Ministernotomy with Sutureless Prosthesis Implantation Compared to Conventional Prosthesis: A Cross-Sectional Study

This study compares cardiopulmonary bypass (CPB) and cross-clamping times in aortic valve replacement surgeries performed via ministernotomy using either sutureless PERCEVAL® or conventional bioprostheses. Among 93 patients, both techniques showed similar outcomes regarding CPB and cross-clamping times, hospital stays, and early postoperative complications. Echocardiographic results improved postoperatively in both groups.

March 21, 2025

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Perfusion News

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

Perioperative Bleeding Is Not an Independent Risk Factor for Acute Kidney Injury in On-pump Cardiac Surgery—A Post-hoc Analysis of a Randomized Clinical Trial

A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

CytoSorb Hemoadsorption of Apixaban During Cardio-Pulmonary Bypass for Heart Transplantation

Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation During Cardiopulmonary Bypass

Cardiopulmonary Bypass and Cross-Clamping Times in Aortic Valve Replacement Surgery by Ministernotomy with Sutureless Prosthesis Implantation Compared to Conventional Prosthesis: A Cross-Sectional Study

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