International Perfusion Association

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IPA

Category: CPB

Heart Transfusion

The Effect of Perioperative Antithrombin Supplementation on Blood Conservation and Postoperative Complications After Cardiopulmonary Bypass Surgery: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

This meta-analysis investigated the effect of perioperative antithrombin (AT) supplementation on patients undergoing cardiopulmonary bypass (CPB) surgery, analyzing 13 randomized controlled trials with 996 participants. The study found that perioperative AT did not significantly reduce postoperative blood loss or the need for blood transfusions, and it was associated with increased in-hospital mortality and acute kidney injury incidence.

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January 4, 2024
Brian CPB

Post-Operative Delirium and Cognitive Dysfunction in Aged Patients Undergoing Cardiac Surgery: A Randomized Comparison between Two Blood Oxygenators

In a study comparing the new oxygenator system RemoweLL 2 with the conventional Inspire device in elderly patients undergoing cardiopulmonary bypass, RemoweLL 2 showed a trend towards reduced incidence of severe post-operative delirium and lower levels of inflammation biomarkers. The study, assessing cognitive decline and inflammation in 154 patients, suggests that advanced CPB oxygenator technologies may lead to better neurocognitive outcomes in the elderly undergoing cardiac surgery.

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December 31, 2023
Cardiac Surgery New Year

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2023 Update on Procedure Data and Research

The Society of Thoracic Surgeons Adult Cardiac Surgery Database, which includes data from over nine million procedures, underpins multiple risk models and has been pivotal in shaping health policy and cardiac surgery practices. This annual report updates on the database’s status, introduces new risk models, details current surgical trends, and outlines research and future directions for this extensive clinical resource.

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December 30, 2023
Delirium CPB

Delirium after Cardiac Surgery-A Narrative Review

Postoperative delirium (POD) following cardiac surgery, potentially influenced by cardiopulmonary bypass, is linked to increased morbidity and mortality despite understanding its causative factors and risk mitigation strategies. This review article discusses the incidence, impact, and primary risk factors of POD in cardiac surgical patients, along with anesthetic and postoperative therapeutic approaches to reduce its occurrence.

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December 30, 2023
Collectrin

Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery

This study explores urinary collectrin as a potential biomarker for early detection of acute kidney injury (AKI) in patients undergoing cardiac surgery with cardiopulmonary bypass. It found significant perioperative changes in collectrin levels, particularly on postoperative day 1, indicating its promise for timely AKI diagnosis and intervention, though further research is needed for clinical validation.

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December 26, 2023

Mechanical Circulatory Support in Cardiogenic Shock

The abstract outlines the evolving management of cardiogenic shock, highlighting the transition to using temporary mechanical circulatory support (t-MCS) like IABP, VA-ECMO, Impella, and ECPELLA, informed by advances in circulatory physiology. It emphasizes the importance of selecting appropriate t-MCS devices based on patient-specific conditions, shock stage, and risk, guided by hemodynamic monitoring and a multidisciplinary team approach.

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December 26, 2023
CPB Time

Association Between Cardiopulmonary Bypass Time and Mortality Among Patients With Acute Respiratory Distress Syndrome After Cardiac Surgery

Longer cardiopulmonary bypass (CPB) times were associated with increased ICU and in-hospital mortality, as well as longer ICU stays, in patients who developed acute respiratory distress syndrome (ARDS) after cardiac surgery. This study suggests that CPB duration is a significant predictor of short-term mortality in these patients, with times over 160.5 minutes increasing the risk of worse outcomes.

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December 24, 2023

Development of New Colloid Osmotic Pressure Measurement Method Using Ultrafiltration Membrane During Cardiopulmonary Bypass

A study developed an ultrafiltration membrane method to measure colloid osmotic pressure (COP) and compared it with colloidal osmometer measurements, finding high accuracy, reproducibility, and positive correlation with existing methods. This new method shows potential for improved COP monitoring in clinical settings, suggesting implications for future research and clinical applications.

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December 22, 2023

Impact of Pre-Bypass Ultrafiltration on Prime Values and Clinical Outcomes in Neonatal and Infant Cardiopulmonary Bypass

Pre-bypass Ultrafiltration (PBUF) was found to standardize and make more physiologic the values for electrolytes, glucose, and lactate in blood primes used for cardiopulmonary bypass in congenital cardiac surgery, without significantly affecting in-hospital outcomes. This retrospective study compared patients ≤ 1 year old undergoing cardiac surgery with PBUF to those without, showing significant improvements in the physiologic values of PBUF-treated circuits.

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December 21, 2023

Our Initial Experience of Monitoring the Autoregulation of Cerebral Blood Flow During Cardiopulmonary Bypass

This study investigates the application of the cerebral oxygenation index (COx) in monitoring cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass surgeries. Despite the complexity and challenges involved, the study emphasizes the critical analysis of COx, highlighting limitations and suggesting caution before its implementation in clinical practice.

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December 20, 2023
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