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Perfusion Association

Protamine

Explore articles, research, and perspectives from the International Perfusion Association.

Illustration of a perfusionist testing a blood sample beside a cardiopulmonary bypass circuit

Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial

A four-center randomized trial compared activated clotting time targets of at least 400 and 480 seconds in 1,021 adults undergoing first-time cardiac surgery with

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Oct 12, 2026

Protamine Dosing and Its Impact in Cardiac Surgery Transfusion Practice: A Retrospective Bi-institutional Analysis

This study investigates the correlation between protamine dosing and transfusion requirements in cardiac surgery, analyzing data from 762 patients who underwent cardiopulmonary bypass (CPB)-assisted

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Feb 5, 2024

Protamine Dose to Neutralize Heparin at the Completion of Cardiopulmonary Bypass Can be Reduced Significantly Without Affecting Post-Operative Bleeding

The study investigated reducing the protamine-to-heparin ratio (P-to-H) from 1:1 to 0.9:1 and 0.8:1 in cardiac surgery patients to determine its effect on post-operative

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Dec 27, 2023