The goal-directed perfusion (GDP) strategy is increasingly adopted in cardiac surgery to maintain optimal perfusion, improving patient outcomes by serving as a quality control tool for monitoring the practice of perfusionists and the use of equipment and disposables. It emphasizes intensive monitoring of respiratory-related parameters, optimal flow, and management of intraoperative parameters to protect end-organ function and enhance surgical outcomes, with the findings advocating for its superiority over traditional perfusion strategies and highlighting the importance of developing protocols within international guidelines.