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Category: CPB

The Rat

The Anti-Apoptotic Effect of Ranolazine on Cerebral Protection during Cardiopulmonary Bypass and Carotid Artery Surgery

This study investigated the neuroprotective effects of ranolazine (Rn) in a rat model of cerebral ischemia induced by carotid artery clamping. Results showed that Rn-treated groups had significant changes in various biochemical markers, indicating an antiapoptotic effect of Rn in brain ischemia-reperfusion, suggesting its potential usability in cardiac surgeries and carotid artery interventions.

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January 25, 2024
Exploding Heart Elephant

Surgical Management and Outcomes of Coronary Artery Involvement Secondary to Acute Type A Aortic Dissection: A Retrospective Cohort Study

In a study of patients with acute type A aortic dissection (ATAAD) undergoing total arch replacement (TAR) and frozen elephant trunk (FET) implantation, it was found that those with coronary artery involvement (CAI) experienced more complicated surgeries, longer hospital stays, and higher rates of in-hospital morbidity and mortality compared to those without CAI. Although coronary artery malperfusion (CAM) due to CAI was an independent risk factor for in-hospital mortality, short-term survival post-discharge was similar between patients with and without CAI.

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January 23, 2024
Blood Hemolysis

Finding a Common Definition of Heparin Resistance in Adult Cardiac Surgery: Communication from the ISTH SSC Subcommittee on Perioperative and Critical Care Thrombosis and Hemostasis

Ensuring sufficient anticoagulation in cardiac surgery and cardiopulmonary bypass is crucial for preventing adverse outcomes. This review evaluates various definitions of heparin resistance in this context, proposing a standardized definition based on the inability to achieve an activated clotting time target of 480 or more after a dose of 500 U/kg of heparin.

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January 21, 2024
Elderly Patient CPB

Risk Factors and Short-Term Outcomes of Postoperative Pulmonary Complications in Elderly Patients After Cardiopulmonary Bypass

This study on elderly patients undergoing cardiopulmonary bypass (CPB) found a high incidence (56.82%) of postoperative pulmonary complications (PPCs), identifying low serum albumin levels, specific types of surgery, prolonged CPB, blood transfusion, and pre-extubation intra-aortic balloon pump use as significant risk factors. These PPCs led to longer mechanical ventilation, extended hospital and ICU stays, increased mortality, and higher tracheotomy rates, highlighting the importance of recognizing these risk factors for better perioperative prevention in elderly CPB patients.

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January 11, 2024
Hypoxic Cell

Prospective Clinical Study Testing the Efficacy and Safety of a New Formula to Increase the Precision of Oxygen Therapy in the Initiation Phase of Cardiopulmonary Bypass

This study developed a formula for tailored oxygen therapy during cardiopulmonary bypass (CPB) to prevent cellular hypoxia and minimize the risk of hyperoxemia. In a pilot study, the formula aimed for a specific arterial partial oxygen pressure (PaO2) range, but only 38.75% of patients achieved the target range, indicating a need for further adjustments to the formula to enhance its effectiveness in guiding oxygen therapy during CPB.

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January 7, 2024
Photo Safety GPT

Simulated Cardiopulmonary Bypass: A High Fidelity Model for Developing and Accessing Clinical Perfusion Skills

The study describes a simulated cardiopulmonary bypass (CPB) model integrated into a mock operative theater, aiming to enhance the training of novice perfusionists. Results from 81 participants indicated high fidelity and effectiveness of the simulation in replicating real CPB scenarios and skills, suggesting its potential for educational use in clinical perfusion training.

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January 5, 2024
Blue CPB

Effects of Blood Transfusion, Cardiopulmonary Bypass Time, and Bypassed Vessels on Mortality Following Isolated and Combined Coronary Artery Bypass Grafting

This study analyzed 677 patients to investigate the correlation between the number of bypassed vessels, cardiopulmonary bypass duration, blood transfusion requirements, revision rates, and mortality in coronary artery bypass grafting surgeries. Results indicated that higher revision rates were associated with six-vessel bypasses, longer bypass and cross-clamp times, increased blood transfusions, and mortality, with specific blood thinners affecting transfusion needs and mortality outcomes.

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January 4, 2024
Heart Transfusion

The Effect of Perioperative Antithrombin Supplementation on Blood Conservation and Postoperative Complications After Cardiopulmonary Bypass Surgery: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

This meta-analysis investigated the effect of perioperative antithrombin (AT) supplementation on patients undergoing cardiopulmonary bypass (CPB) surgery, analyzing 13 randomized controlled trials with 996 participants. The study found that perioperative AT did not significantly reduce postoperative blood loss or the need for blood transfusions, and it was associated with increased in-hospital mortality and acute kidney injury incidence.

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January 4, 2024
Brian CPB

Post-Operative Delirium and Cognitive Dysfunction in Aged Patients Undergoing Cardiac Surgery: A Randomized Comparison between Two Blood Oxygenators

In a study comparing the new oxygenator system RemoweLL 2 with the conventional Inspire device in elderly patients undergoing cardiopulmonary bypass, RemoweLL 2 showed a trend towards reduced incidence of severe post-operative delirium and lower levels of inflammation biomarkers. The study, assessing cognitive decline and inflammation in 154 patients, suggests that advanced CPB oxygenator technologies may lead to better neurocognitive outcomes in the elderly undergoing cardiac surgery.

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December 31, 2023
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