Comparison of Cardioplegic Solutions in Coronary Bypass Surgery Over Autophagy and Apoptosis Mechanisms

January 28, 2024 No Comments

This study aimed to examine myocardial damage at the molecular level in coronary bypass surgery patients, focusing on autophagy and apoptosis mechanisms. It found no significant difference in myocardial protection between Custodiol cardioplegia (CC) and Blood cardioplegia (BC) solutions, despite variations in BECLIN and CASPASE gene expressions in myocardial tissues.

Ultrasound Study of Right Ventricular Myocardial Perfusion and Functional Changes in Hypertrophic Cardiomyopathy

January 27, 2024 No Comments

This study aimed to develop a dynamic predictive model for cardiac surgery-associated acute kidney injury (CSA-AKI), using data from 910 cardiac surgery patients to combine preoperative risks and cardiopulmonary bypass (CPB) related factors into a multifactorial dynamic perfusion index (MDPI). The study found that the MDPI, which includes dynamic CPB quality indices, has better predictive ability for CSA-AKI than existing static models, suggesting its potential as a more effective tool for integrating various risk factors in patient care.

Randomized Controlled Trial of Remote Ischemic Preconditioning in Children Having Cardiac Surgery

January 6, 2024 No Comments

In a study on children undergoing cardiac surgery, remote ischemic preconditioning showed a potential for reducing kidney injury, but there were no significant differences in cardiac markers or secondary clinical outcomes. Although there was a minor trend towards kidney protection, larger studies are needed to confirm the efficacy of this intervention in a high-risk pediatric population.

Myocardial Protection with Phosphocreatine in High-Risk Cardiac Surgery Patients: A Randomized Trial

January 5, 2024 No Comments

This study tested if phosphocreatine (PCr) reduces troponin I levels in cardiac surgery patients with prolonged aortic clamping and cardiopulmonary bypass. Although PCr was safely administered, it did not lead to a decrease in troponin I concentration or improve other clinical outcomes after surgery.

Outcomes of Coronary Artery Bypass Surgery Using Modified del Nido Cardioplegia in Patients With Poor Ventricular Function

December 6, 2023 No Comments

del Nido cardioplegia (DN) has been shown to be safe in adult patients undergoing isolated coronary artery bypass grafting with normal left ventricular ejection fraction. We sought to determine whether it was also safe in adult patients with diminished left ventricular function.

Myocardial Protection With Phosphocreatine in High-Risk Cardiac Surgery Patients: A Randomized Trial

December 3, 2023 No Comments

This study was conducted to test the hypothesis that phosphocreatine (PCr), administered intravenously and as cardioplegia adjuvant in patients undergoing cardiac surgery with prolonged aortic cross clamping and cardiopulmonary bypass (CPB) time, would decrease troponin I concentration after surgery.

Custodiol Versus Blood Cardioplegia in Pediatric Cardiac Surgery: A Randomized Controlled Trial

November 29, 2023 No Comments

This study aimed to test whether custadiol is not inferior to blood-based cardioplegia in pediatric cardiac surgery.

Non-selective Del Nido and St Thomas Cardioplegia in Adults: Analysis of Early Clinical Experience Using Propensity Matching

November 24, 2023 No Comments

Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges.

Redosing of Long Acting Cardioplegic Solutions in Adult Cardiac Surgery: A Comparative Study

September 6, 2022 No Comments

Despite promising results regarding using long-acting cardioplegia in the adult population, little data exists specifically for operations requiring prolonged aortic cross-clamp needing additional doses. In this pilot study, we evaluated the outcomes of patients undergoing surgery with prolonged cross-clamp time based on four different redosing compositions.