This study evaluates three arterial catheter placement strategies (Radial Short, Radial Long, and Brachial Long) for hemodynamic monitoring in cardiac surgery. Conducted at a single academic university hospital, it involved adult patients undergoing non-emergent cardiac surgery with cardiopulmonary bypass. The findings indicate that both Radial Long and Brachial Long catheter placements offer superior systemic systolic arterial pressure (SAP) and mean arterial pressure (MAP) monitoring compared to the Radial Short strategy. Specifically, the Brachial Long placement showed superior results in MAP gradients post-CPB, and lesser need for femoral line placement and vasopressin administration, underscoring the effectiveness of longer catheters in critical care.