Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke

January 23, 2024 No Comments

This study explored how age impacts the functional outcome in patients with acute ischemic stroke who received endovascular thrombectomy (EVT), and found that the association between age and 90-day outcome was largely mediated by neuroimaging markers of frailty, such as brain atrophy and small vessel disease, highlighting the significance of these features beyond chronological age in predicting poststroke outcomes. The study suggests that future trials could consider incorporating frailty markers to better assess and adjust for poststroke outcomes.

Serum CIRP Increases the Risk of Acute Kidney Injury After Cardiac Surgery

January 21, 2024 No Comments

The study aimed to investigate the role of cold-induced RNA-binding protein (CIRP) in the development of acute kidney injury (AKI) following cardiac surgery. Elevated extracellular CIRP levels, particularly associated with prolonged cardiopulmonary bypass (CPB) time, were identified as independent risk factors for postoperative AKI, especially severe cases, highlighting its correlation with adverse in-hospital outcomes.

Empower a Heart, Save a Life: The Honduras Open Heart Surgery Initiative

January 20, 2024 No Comments

Since 2019, a global health initiative in Tegucigalpa, Honduras, has been empowering local healthcare professionals to perform essential open heart surgeries, crucial in a country where such medical care is rare and desperately needed. Facing challenges like the high cost of surgeries against the backdrop of low average incomes, the program aims to develop local expertise while contending with economic barriers, and in 2024, it plans an ambitious mission with teams from Duke and Harvard, seeking contributions to continue saving lives and enhancing cardiac care in Honduras.

Donor Heart Preservation: Current Knowledge and the New Era of Machine Perfusion

January 17, 2024 No Comments

Heart transplantation traditionally employs static cold storage for donor preservation, but this method carries a risk of early graft dysfunction due to ischemic and reperfusion injury. Emerging preservation techniques, such as hypothermic or normothermic machine perfusion, offer the promise of improved graft protection, the ability to repair organs, and the evaluation of graft function prior to transplantation, potentially expanding the donor pool with the aid of new pharmacological treatments.

Trends in the Use of Recombinant Activated Factor VII and Prothrombin Complex Concentrate in Heart Transplant Patients in Virginia

January 16, 2024 No Comments

The study investigated the use of procoagulant factors during heart transplants in Virginia and their potential link to postoperative thrombosis. It found a decrease in the use of off-label recombinant activated factor VII (rFVIIa) but an increase in off-label prothrombin complex concentrate (PCC) use, with rFVIIa associated with a higher risk of thrombosis, although patients receiving it were more critically ill, which may have influenced the results.

Redo Aortic Surgery: Does One Versus Multiple Affect Outcomes?

January 15, 2024 No Comments

This study compares outcomes in patients undergoing redo aortic surgery after one versus multiple previous cardiac operations, finding that multiple redo surgeries are associated with higher short-term mortality and morbidity but similar long-term survival compared to first redo surgeries. Despite similar rates of postoperative complications, multiple redo surgeries have longer cardiopulmonary bypass and crossclamp times, and a higher incidence of dialysis.

Outcomes of Total Aortic Arch Replacement in a Canadian Nationwide Registry

January 14, 2024 No Comments

This multicenter study compares outcomes of 250 elective total arch replacements with 728 elective hemiarch replacements in Canada, using propensity score matching to create 202 well-matched pairs. Findings reveal that while in-hospital mortality rates for total arch replacement are comparable to hemiarch repairs, total arch replacement is associated with higher rates of complications such as delirium and prolonged intubation.

The Usefulness of Contrast Echocardiography in the Evaluation of Cardiac Masses: A Multicenter Study

January 14, 2024 No Comments

This study evaluates the diagnostic accuracy of Contrast Echocardiography (CE) in differentiating between thrombi, benign, and malignant cardiac masses, using a multicenter prospective approach on 145 patients. The results indicate high accuracy of CE, with optimal A1/A2 cutoff values showing strong sensitivity and specificity in distinguishing different types of cardiac masses.

Techniques and Technologies to Improve Vein Graft Patency in Coronary Surgery

January 13, 2024 No Comments

Vein grafts, commonly used in coronary artery bypass grafting (CABG), have lower patency rates than arterial options, and this review examines methods to improve their quality, identifying preoperative and postoperative therapies and no-touch harvesting as most effective. Additionally, the review suggests re-doing CABG and primary coronary intervention on native vessels as the best strategies for treating vein graft failure, with percutaneous procedures as a secondary option.

The Overall Prevalence and Main Determinants of Prolonged Mechanical Ventilation in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review

January 12, 2024 No Comments

This systematic review found that the prevalence of prolonged mechanical ventilation (PMV) in patients undergoing coronary artery bypass grafting (CABG) surgery ranges from 1.7% to 10.2%, depending on the definition of PMV. The study identified several predictors of PMV, including demographic factors, obesity, comorbidities, emergency surgery, intraoperative characteristics, and certain postoperative outcomes, which could help in designing new scoring systems for predicting PMV.