International Perfusion Association

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IPA

Category: Cardiac Surgery

CABG Core

Safety-Net Hospital Status Is Associated With Coronary Artery Bypass Grafting Outcomes at an Urban Academic Medical Center

The study investigated the impact of socioeconomic factors and referral status from a county hospital (CH) on outcomes of coronary artery bypass grafting (CABG). It found that patients from CH had greater comorbidities, more often required nonelective surgery, and faced a significantly higher risk of major adverse cardiovascular events (MACE) postoperatively.

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January 26, 2024
The Rat

The Anti-Apoptotic Effect of Ranolazine on Cerebral Protection during Cardiopulmonary Bypass and Carotid Artery Surgery

This study investigated the neuroprotective effects of ranolazine (Rn) in a rat model of cerebral ischemia induced by carotid artery clamping. Results showed that Rn-treated groups had significant changes in various biochemical markers, indicating an antiapoptotic effect of Rn in brain ischemia-reperfusion, suggesting its potential usability in cardiac surgeries and carotid artery interventions.

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January 25, 2024
Mohamed Mohamed

GPT Serum CIRP Increases the Risk of Acute Kidney Injury After Cardiac Surgery

This study explored the connection between elevated Cold-induced RNA-binding protein (CIRP) levels and the incidence of acute kidney injury (AKI) following cardiac surgery, focusing on surgeries involving cardiopulmonary bypass (CPB). It was discovered that higher CIRP levels, especially in surgeries with CPB, are independently associated with a higher risk of developing AKI, leading to worse postoperative outcomes, including a lower survival rate over two years.

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January 25, 2024
Saudi Aortic Dissection

Retrograde Type A Acute Aortic Dissection With Cerebral Malperfusion Six Years After Thoracic Endovascular Aortic Repair

A 59-year-old male, previously treated with thoracic endovascular aortic repair (TEVAR), developed retrograde type A aortic dissection, leading to cerebral infarction and carotid artery occlusion. He underwent successful total arch replacement and carotid artery bypass, followed by rehabilitation, highlighting the complex challenges and critical interventions needed for TEVAR complications.

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January 24, 2024
Exploding Heart Elephant

Surgical Management and Outcomes of Coronary Artery Involvement Secondary to Acute Type A Aortic Dissection: A Retrospective Cohort Study

In a study of patients with acute type A aortic dissection (ATAAD) undergoing total arch replacement (TAR) and frozen elephant trunk (FET) implantation, it was found that those with coronary artery involvement (CAI) experienced more complicated surgeries, longer hospital stays, and higher rates of in-hospital morbidity and mortality compared to those without CAI. Although coronary artery malperfusion (CAM) due to CAI was an independent risk factor for in-hospital mortality, short-term survival post-discharge was similar between patients with and without CAI.

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January 23, 2024
Simpson Rehabilitation

Cardiac Rehabilitation and Acute Aortic Dissection: Understanding and Addressing the Evidence GAP A Systematic Review

Despite established guidelines, there’s a lack of concrete strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD), particularly regarding how to adapt guidelines for different patient variables. A systematic review covering 2004-2023 found limited evidence but generally positive outcomes from CR in AAD patients, with improvements in exercise capacity and quality of life, suggesting the need for a well-designed trial to explore CR’s benefits in this high-risk group.

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January 23, 2024
Brain Photo

Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke

This study explored how age impacts the functional outcome in patients with acute ischemic stroke who received endovascular thrombectomy (EVT), and found that the association between age and 90-day outcome was largely mediated by neuroimaging markers of frailty, such as brain atrophy and small vessel disease, highlighting the significance of these features beyond chronological age in predicting poststroke outcomes. The study suggests that future trials could consider incorporating frailty markers to better assess and adjust for poststroke outcomes.

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January 23, 2024
Machine Learning AKI

Serum CIRP Increases the Risk of Acute Kidney Injury After Cardiac Surgery

The study aimed to investigate the role of cold-induced RNA-binding protein (CIRP) in the development of acute kidney injury (AKI) following cardiac surgery. Elevated extracellular CIRP levels, particularly associated with prolonged cardiopulmonary bypass (CPB) time, were identified as independent risk factors for postoperative AKI, especially severe cases, highlighting its correlation with adverse in-hospital outcomes.

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January 21, 2024
Donation Request

Empower a Heart, Save a Life: The Honduras Open Heart Surgery Initiative

Since 2019, a global health initiative in Tegucigalpa, Honduras, has been empowering local healthcare professionals to perform essential open heart surgeries, crucial in a country where such medical care is rare and desperately needed. Facing challenges like the high cost of surgeries against the backdrop of low average incomes, the program aims to develop local expertise while contending with economic barriers, and in 2024, it plans an ambitious mission with teams from Duke and Harvard, seeking contributions to continue saving lives and enhancing cardiac care in Honduras.

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January 20, 2024
Heart Transplantation

Donor Heart Preservation: Current Knowledge and the New Era of Machine Perfusion

Heart transplantation traditionally employs static cold storage for donor preservation, but this method carries a risk of early graft dysfunction due to ischemic and reperfusion injury. Emerging preservation techniques, such as hypothermic or normothermic machine perfusion, offer the promise of improved graft protection, the ability to repair organs, and the evaluation of graft function prior to transplantation, potentially expanding the donor pool with the aid of new pharmacological treatments.

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January 17, 2024
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