An in vitro Comparison of Intra-Operative Isohemagglutinin and Human Leukocyte Antigen Removal Techniques in Pediatric Heart Transplantation

December 21, 2023 No Comments

This study compared two plasmapheresis techniques, membrane-based (MP) and centrifuge-based (CP), for their effectiveness in reducing isohemagglutinin titers (IT) and human leukocyte antigen (HLA) antibodies in highly sensitized pediatric patients awaiting heart transplants. Both methods, incorporated into extracorporeal circuits, effectively reduced circulating antibodies, with CP showing slightly greater efficiency in reducing ITs and anti-HLA class II antibody mean fluorescence intensity, although further in vivo studies are needed for confirmation.

Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery

December 21, 2023 No Comments

This study investigates the adsorption of propofol in extracorporeal membrane oxygenation (ECMO) circuits, noting that drugs prescribed to ECMO patients often lack optimized dosing strategies due to the circuit’s ability to adsorb drugs. It found that while only 27% of propofol was recovered after a bolus dose, more than 80% was recovered following a continuous infusion, suggesting direct dosing into ECMO circuits could mitigate altered drug exposure due to adsorption.

Our Initial Experience of Monitoring the Autoregulation of Cerebral Blood Flow During Cardiopulmonary Bypass

December 20, 2023 No Comments

This study investigates the application of the cerebral oxygenation index (COx) in monitoring cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass surgeries. Despite the complexity and challenges involved, the study emphasizes the critical analysis of COx, highlighting limitations and suggesting caution before its implementation in clinical practice.

Platelet Reduction after Aortic Bioprosthesis Implantation: Results from the PORTRAIT Study

December 20, 2023 No Comments

Platelet count reduction (PR) is a common but unclear phenomenon that occurs after aortic bioprosthesis valve implantation (bio-AVR). This study aimed to investigate the occurrence and clinical impact of PR in patients receiving stented, rapid deployment (RDV), or stentless bioprostheses.

Pro: Individualized Optimal Perfusion Pressure- Maximizing Patient Care During Cardiopulmonary Bypass

December 20, 2023 No Comments

Exploring techniques like multimodal intravenous anesthesia guided by electroencephalogram can enhance perfusion maintenance within the auto-regulatory range. By adopting an individualized approach to perfusion targets on CPB, we can improve outcomes and enhance patient care.

Comparison of 6% Hydroxyethyl Starch 130/0.4 and Ringer’s Lactate as Priming Solutions in Patients Undergoing Isolated Open Heart Valve Surgery: A Double-Blind Randomized Controlled Trial

December 18, 2023 No Comments

This study compared the outcomes of heart valve surgery patients undergoing cardiopulmonary bypass with two different priming solutions: 6% hydroxyethyl starch (HES) 130/0.4 and ringer’s lactate (RL). The results indicate that using HES in addition to RL for priming increased the risk of blood product transfusion during hospitalization compared to using RL alone in this patient population.

Impact of Pre-bypass Ultrafiltration on Prime Values and Clinical Outcomes in Neonatal and Infant Cardiopulmonary Bypass

December 16, 2023 No Comments

We aimed to determine if using PBUF on blood primes including packed red blood cells and thawed plasma would make prime values more predictable and physiologic. Additionally, we aimed to evaluate whether the addition of PBUF had an impact on outcome measures.

Cardiopulmonary Bypass Management and Acute Kidney Injury in Cardiac Surgery Patients

December 15, 2023 No Comments

Cardiopulmonary bypass (CPB) ensures tissue oxygenation during cardiac surgery. New technology allows continuous registration of CPB variables during the operation. The aim of the present investigation was to study the association between CPB management and the risk of postoperative acute kidney injury (AKI).

Patient Blood Management and Its Role in Supporting Blood Supply

December 10, 2023 No Comments

The review highlights how these different aspects of blood donation are integral to a successful PBM program and the safety of patients who receive blood transfusions.

Utility of Heparin-Binding Protein Following Cardiothoracic Surgery Using Cardiopulmonary Bypass

December 9, 2023 No Comments

This study confirms the promising characteristics of HBP as a biomarker for identification of postoperative sepsis, especially after routine procedures. Further studies are required to investigate whether HBP may detect postoperative infections.

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An in vitro Comparison of Intra-Operative Isohemagglutinin and Human Leukocyte Antigen Removal Techniques in Pediatric Heart Transplantation

Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery

Our Initial Experience of Monitoring the Autoregulation of Cerebral Blood Flow During Cardiopulmonary Bypass

Platelet Reduction after Aortic Bioprosthesis Implantation: Results from the PORTRAIT Study

Pro: Individualized Optimal Perfusion Pressure- Maximizing Patient Care During Cardiopulmonary Bypass

Comparison of 6% Hydroxyethyl Starch 130/0.4 and Ringer’s Lactate as Priming Solutions in Patients Undergoing Isolated Open Heart Valve Surgery: A Double-Blind Randomized Controlled Trial

Impact of Pre-bypass Ultrafiltration on Prime Values and Clinical Outcomes in Neonatal and Infant Cardiopulmonary Bypass

Cardiopulmonary Bypass Management and Acute Kidney Injury in Cardiac Surgery Patients

Patient Blood Management and Its Role in Supporting Blood Supply

Utility of Heparin-Binding Protein Following Cardiothoracic Surgery Using Cardiopulmonary Bypass

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