Multi-Method Investigation of Blood Damage Induced by Blood Pumps in Different Clinical Support Modes

January 14, 2024 No Comments

This study investigates the impact of different operational modes of an extracorporeal blood pump (CentriMag) on blood flow patterns and the associated risks of bleeding, thrombosis, and hemolysis using computational fluid dynamics and hemocompatibility models. It finds that venous-arterial (V-A) ECMO mode results in the highest risk of these complications, with heart failure (HF) mode being the least risky, largely due to variations in flow patterns affecting cell and protein functions.

Effects of Blood Transfusion, Cardiopulmonary Bypass Time, and Bypassed Vessels on Mortality Following Isolated and Combined Coronary Artery Bypass Grafting

January 4, 2024 No Comments

This study analyzed 677 patients to investigate the correlation between the number of bypassed vessels, cardiopulmonary bypass duration, blood transfusion requirements, revision rates, and mortality in coronary artery bypass grafting surgeries. Results indicated that higher revision rates were associated with six-vessel bypasses, longer bypass and cross-clamp times, increased blood transfusions, and mortality, with specific blood thinners affecting transfusion needs and mortality outcomes.

The Effect of Perioperative Antithrombin Supplementation on Blood Conservation and Postoperative Complications After Cardiopulmonary Bypass Surgery: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

January 4, 2024 No Comments

This meta-analysis investigated the effect of perioperative antithrombin (AT) supplementation on patients undergoing cardiopulmonary bypass (CPB) surgery, analyzing 13 randomized controlled trials with 996 participants. The study found that perioperative AT did not significantly reduce postoperative blood loss or the need for blood transfusions, and it was associated with increased in-hospital mortality and acute kidney injury incidence.

Early Blood Clot Detection Using Forward Scattering Light Measurements Is Not Superior to Delta Pressure Measurements

January 3, 2024 No Comments

This study investigates the use of forward scattered light (FSL) measurements for early blood clot detection in extracorporeal membrane oxygenators, a method potentially superior to the current standard of monitoring pressure differences (ΔP) which fails to detect smaller, early-stage clots. Despite several modifications, FSL measurements were unable to reliably detect clots in an in vitro test circuit, whereas the current clinical gold standard of pressure measurements successfully detected fulminant clot formation in multiple experiments.

Using Cardiohelp, Quadrox, and Nautilus Extracorporeal Membrane Oxygenators as Vascular Access for Hemodialysis, Continuous Renal Replacement Therapy, and Plasmapheresis: A Brief Technical Report

January 2, 2024 No Comments

This technical report details methods for performing dialytic therapies, such as intermittent hemodialysis (iHD) and continuous renal replacement therapy (CRRT), safely and effectively through an ECMO circuit, eliminating the need for a separate dialysis catheter in patients with acute kidney injury (AKI) and end-stage renal disease (ESRD). It outlines the connection of these kidney replacement therapies to various oxygenators and discusses performing plasmapheresis alongside ECMO and iHD or CRRT, emphasizing the technique’s safety as it doesn’t require modifications to ECMO cannulas/tubing.

Percutaneous Debulking of Tricuspid Valve Infective Endocarditis Vegetations Using a Large Bore Manual Aspiration Device – AlphaVac

December 31, 2023 No Comments

While most infectious endocarditis cases are managed medically, non-responsive patients or those with complications like septic emboli may need mechanical interventions such as AngioVac, which has limitations like the need for a perfusionist and large-bore accesses. The AlphaVac system, omitting the motor element, offers a simpler alternative for manual percutaneous aspiration of tricuspid valve vegetations, as demonstrated in two reported cases.

Protamine Dose to Neutralize Heparin at the Completion of Cardiopulmonary Bypass Can be Reduced Significantly Without Affecting Post-Operative Bleeding

December 27, 2023 No Comments

The study investigated reducing the protamine-to-heparin ratio (P-to-H) from 1:1 to 0.9:1 and 0.8:1 in cardiac surgery patients to determine its effect on post-operative bleeding. Results showed a significant reduction in the actual protamine dose without an increase in post-op bleeding, suggesting that a ratio as low as 0.75:1 might be sufficient for effective neutralization of heparin.

Investigating the Complications and Causes of Failure of the AngioVac System: A Post-Marketing Surveillance From the MAUDE Database

December 22, 2023 No Comments

The AngioVac aspiration thrombectomy device, approved for removing thrombi during bypass, has been reported to commonly fail due to physical damage and is associated with adverse events such as pulmonary embolism and vessel perforation, as per data from the Manufacturer and User Facility Device Experience database between April 2013 and March 2022. Physicians should be cognizant of these potential complications and the fact that the device’s most frequent failures are attributed to its physical damage.

An in vitro Comparison of Intra-Operative Isohemagglutinin and Human Leukocyte Antigen Removal Techniques in Pediatric Heart Transplantation

December 21, 2023 No Comments

This study compared two plasmapheresis techniques, membrane-based (MP) and centrifuge-based (CP), for their effectiveness in reducing isohemagglutinin titers (IT) and human leukocyte antigen (HLA) antibodies in highly sensitized pediatric patients awaiting heart transplants. Both methods, incorporated into extracorporeal circuits, effectively reduced circulating antibodies, with CP showing slightly greater efficiency in reducing ITs and anti-HLA class II antibody mean fluorescence intensity, although further in vivo studies are needed for confirmation.

Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery

December 21, 2023 No Comments

This study investigates the adsorption of propofol in extracorporeal membrane oxygenation (ECMO) circuits, noting that drugs prescribed to ECMO patients often lack optimized dosing strategies due to the circuit’s ability to adsorb drugs. It found that while only 27% of propofol was recovered after a bolus dose, more than 80% was recovered following a continuous infusion, suggesting direct dosing into ECMO circuits could mitigate altered drug exposure due to adsorption.

Social:

Multi-Method Investigation of Blood Damage Induced by Blood Pumps in Different Clinical Support Modes

Effects of Blood Transfusion, Cardiopulmonary Bypass Time, and Bypassed Vessels on Mortality Following Isolated and Combined Coronary Artery Bypass Grafting

The Effect of Perioperative Antithrombin Supplementation on Blood Conservation and Postoperative Complications After Cardiopulmonary Bypass Surgery: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

Early Blood Clot Detection Using Forward Scattering Light Measurements Is Not Superior to Delta Pressure Measurements

Using Cardiohelp, Quadrox, and Nautilus Extracorporeal Membrane Oxygenators as Vascular Access for Hemodialysis, Continuous Renal Replacement Therapy, and Plasmapheresis: A Brief Technical Report

Percutaneous Debulking of Tricuspid Valve Infective Endocarditis Vegetations Using a Large Bore Manual Aspiration Device – AlphaVac

Protamine Dose to Neutralize Heparin at the Completion of Cardiopulmonary Bypass Can be Reduced Significantly Without Affecting Post-Operative Bleeding

Investigating the Complications and Causes of Failure of the AngioVac System: A Post-Marketing Surveillance From the MAUDE Database

An in vitro Comparison of Intra-Operative Isohemagglutinin and Human Leukocyte Antigen Removal Techniques in Pediatric Heart Transplantation

Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery

Help Mend a Heart!

Learn More

Action

Contact

Follow us

© 2025 International Perfusion Association