This study investigates the impact of pulsatile and non-pulsatile cardiopulmonary bypass (CPB) techniques on cerebral perfusion in coronary artery bypass grafting surgeries. Using near-infrared spectroscopy for cerebral oximetry monitoring, S100β protein levels, and neurocognitive function tests, it was found that pulsatile perfusion may offer benefits for cerebral perfusion based on specific biomarker levels, despite no significant differences in neurocognitive outcomes between groups. The findings suggest further research is needed to fully understand the advantages of pulsatile flow for cerebral health post-surgery.