The Combined Use of HA380 Hemoperfusion in Cardiopulmonary Bypass Alleviates Postoperative Inflammatory Response and Organ Dysfunction Following Cardiac Surgery

April 6, 2026 No Comments

This randomized single-center trial evaluated 65 patients undergoing elective cardiac surgery with cardiopulmonary bypass and found that adding the HA380 hemoperfusion cartridge reduced early postoperative inflammatory cytokines, including IL-1β, IL-6, IL-8, and IL-10. The HA380 group also had lower vasoactive-inotropic requirements and better short-term liver and kidney laboratory markers, although ICU ventilation time and ICU stay were not significantly improved.

OCEAN Trial Crossroads: M-TEER in Advanced Heart Failure

Outcomes of Transcatheter Edge-to-Edge Repair in Potentially Favorable Candidates for Left Ventricular Assist Device: Evidence From the OCEAN-Mitral Registry

March 26, 2026 No Comments

This study evaluated mitral transcatheter edge-to-edge repair (M-TEER) in advanced heart failure patients who might otherwise have been reasonable candidates for left ventricular assist device (LVAD) therapy. Among 129 such patients from the OCEAN-Mitral Registry, procedural success was high at 96%, but long-term outcomes were less reassuring, especially in those with marked left ventricular enlargement. Larger LV size predicted cardiovascular death after M-TEER.

Equity in Cardiac Surgery: Bridging the Gap in Mitral Valve Care

Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions

March 22, 2026 No Comments

This retrospective study of 3,313 patients undergoing mitral valve surgery found that women presented older, with more advanced heart failure, and were less likely to receive valve repair. Despite these differences, operative mortality did not significantly differ between sexes after adjustment. Women experienced longer ICU and hospital stays, highlighting disparities in recovery rather than survival outcomes.

Cybersecurity as It Relates to Perfusion

March 21, 2026 No Comments

Cybersecurity is increasingly critical in perfusion as connected medical devices expand vulnerability within hospital networks. Perfusionists must understand risks associated with the Internet of Medical Things (IoMT), adopt strong digital practices, and collaborate with IT teams. The article highlights downtime preparedness, device security awareness, and standardized guidelines to protect patient data and maintain safe clinical operations.

MIDCAB vs Drug-Eluting Stent: Two Paths to LAD Revascularization

Revascularization of Left Anterior Descending Artery with Minimally Invasive Direct Coronary Artery Bypass Graft vs. Drug Eluting Stents: A Retrospective, Two-Center Study

March 15, 2026 No Comments

This retrospective two-center study compared long-term outcomes of minimally invasive direct coronary artery bypass (MIDCAB) with drug-eluting stent (DES) percutaneous coronary intervention for left anterior descending (LAD) artery disease. Among matched patient groups, MIDCAB resulted in significantly lower rates of recurrent angina and repeat revascularization within two years. However, long-term survival up to 20 years was similar between both treatments. The findings support MIDCAB as a durable alternative for LAD revascularization.

Viscoelastic Monitoring Guiding Hemostasis During Cardiac Surgery

A Prospective Analysis of Viscoelastic Assays, Platelet Aggregometry, and Standard Laboratory Tests in Predicting Perioperative Blood Loss in Cardiac Surgery

March 14, 2026 No Comments

This prospective observational study of 79 cardiac surgery patients evaluated whether viscoelastic testing (ROTEM), platelet aggregometry, or standard coagulation tests best predict perioperative bleeding. Clot firmness measured by FIBTEM A10 strongly correlated with blood loss using the Hb/kg Index, while platelet count, platelet aggregation, and conventional tests did not. A FIBTEM A10 cutoff of 12 mm accurately detected hypofibrinogenemia, supporting fibrinogen-focused transfusion strategies.

Rethinking Cardiopulmonary Bypass Management in the Digital Health Era

March 7, 2026 No Comments

Minimally invasive and robotic cardiac surgery reduce surgical trauma and speed recovery but often require longer cardiopulmonary bypass (CPB) times, increasing risks such as renal injury, neurological complications, and systemic inflammation. This review explores how digital health tools—including continuous physiologic monitoring, machine learning analytics, and digital twin simulations—can transform CPB from a static procedural metric into a dynamically optimized variable, enabling personalized perfusion strategies that improve safety and outcomes in modern cardiac surgery.

Cardiopulmonary Bypass Supporting High-Risk PCI and TAVR

Cardiopulmonary Bypass as Safe and Effective Support for Concomitant High-Risk Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement

February 28, 2026 No Comments

This study evaluates the safety and effectiveness of cardiopulmonary bypass (CPB) as hemodynamic support during combined high-risk percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). The authors demonstrate that CPB provides stable circulatory support, enabling complete revascularization and valve implantation in complex patients with severe coronary artery disease and aortic stenosis, with acceptable complication rates and favorable procedural outcomes.

Predictors of Prolonged Intensive Care Unit Stay and In-Hospital Mortality Following Cardiac Surgery: An Integrated Analysis from the PROCARD-ATI Study

April 27, 2025 No Comments

This study analyzed 130 adult cardiac surgery patients to identify perioperative predictors of prolonged ICU stays and in-hospital mortality. Results revealed aortic cross-clamp time (AXCT) as the sole independent predictor of ICU stays ≥7 days, with a threshold of 110 minutes. For mortality, prolonged cardiopulmonary bypass time (CPBT), emergency surgery, and higher AXCT were key predictors. The findings suggest practical intraoperative benchmarks to enhance surgical strategies and outcomes.

Near-Infrared Spectroscopy to Monitor Cerebral and Renal Oxygen Saturation During Cardiopulmonary Bypass Surgery for Paediatric Congenital Heart Disease: Study Protocol for a Prospective Observational Cohort Trial

April 10, 2025 No Comments

This BMJ Open study outlines a prospective cohort trial evaluating near-infrared spectroscopy (NIRS) to monitor cerebral and renal oxygen saturation during pediatric cardiopulmonary bypass surgery. It aims to link intraoperative oxygenation levels with postoperative brain and kidney injuries, assessing outcomes with biomarkers and quality-of-life metrics. Findings could improve organ injury prediction and perioperative care in congenital heart disease surgeries.