Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate Cardioplegia Solutions: An Animal Study With Prolonged Ischaemia

April 3, 2025 No Comments

This study compares Del Nido (DN) and Bretschneider histidine-tryptophan-ketoglutarate (HTK) cardioplegia solutions in a porcine model of prolonged ischaemia. DN demonstrated superior left ventricular function, spontaneous return to sinus rhythm, and less haemodilution and endothelial dysfunction compared to HTK. Histological and biochemical markers of injury, stress, and apoptosis showed no significant differences, suggesting DN offers enhanced myocardial protection during cardiac surgery.

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

April 3, 2025 No Comments

This non-inferiority study evaluates the Quantum Perfusion System (QPS) for continuous blood gas monitoring during cardiopulmonary bypass (CPB) against the standard blood gas analyzer (BGA). Using data from 40 patients undergoing cardiac surgeries, QPS demonstrated high accuracy and agreement with BGA across all key parameters, adhering to Clinical Laboratory Improvement Amendments (CLIA) standards, and validating its utility as a trending device.

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

April 2, 2025 No Comments

The article explores the safety and effectiveness of the MANTA vascular closure device for managing large-bore arteriotomy, particularly post-decannulation in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients. Findings suggest the MANTA device reduces vascular complications and offers a viable, low-risk option for critically ill patients, though further high-powered studies are needed to confirm superiority over other closure methods.

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

March 30, 2025 No Comments

This study presents the development of a novel optical CO₂ sensor for use in extracorporeal life support (ECLS) systems such as ECMO and ECCO₂R. The sensor accurately measures CO₂ concentration in oxygenator exhaust gas and gas flow to determine CO₂ removal rates. A built-in heating system prevents condensation, and a temperature control algorithm ensures measurement accuracy. Laboratory and in vivo validations confirm its clinical suitability.

The Feasibility of Centralized Application Services for Perfusion Education Programs

March 13, 2025 No Comments

Perfusion education programs have grown significantly in the U.S. over the past 30 years, with increasing accreditation and student enrollment. This study explores the benefits of a centralized application service (CAS) for perfusion programs, highlighting cost reductions and streamlined admissions. With rising demand for perfusionists, a CAS could improve accessibility, efficiency, and applicant diversity, ultimately strengthening the profession’s future.

Development and Validation of a Nomogram for Predicting Perioperative Transfusion in Children Undergoing Cardiac Surgery with CPB

February 3, 2025 No Comments

This study develops and validates a predictive model for perioperative red blood cell transfusion (PRT) risk in pediatric cardiac surgery with cardiopulmonary bypass (CPB). Using data from 19,155 children, eight key predictors—including age, weight, preoperative hemoglobin, CPB duration, and cyanotic congenital heart disease—were identified. The nomogram demonstrated high accuracy (AUC 0.886) and clinical utility, aiding personalized blood management strategies to optimize outcomes and reduce transfusion risks.

The Incidence, Risk Factors, and Hospital Mortality of Prolonged Mechanical Ventilation Among Cardiac Surgery Patients: A Systematic Review and Meta-Analysis

December 20, 2024 No Comments

This systematic review analyzes prolonged mechanical ventilation (PMV) post-cardiac surgery, finding an incidence rate of 20%. PMV, defined as ventilation lasting ≥24 hours, is linked to in-hospital mortality (odds ratio: 14.13). Key risk factors include advanced age, female sex, ejection fraction <50%, and body mass index >28 kg/m². PMV also correlates with conditions like chronic renal failure and prolonged cardiopulmonary bypass time. These insights highlight the need for targeted prevention and management strategies.

A New Protocol for Removal of the Endothelium from the Perfused Rat Hind-Limb Preparation

December 10, 2024 No Comments

This study introduces a novel method for selectively removing endothelial cells from rat hind-limb arteries using a high flow/air bubbles/high flow protocol. The technique effectively removes endothelium from larger arteries without damaging smooth muscle cells, arterioles, or capillaries. It enhances vascular reactivity, as shown by increased contractile responses to a,β-methylene ATP. This method provides a model for investigating vascular function with and without endothelial influence.

Efficacy and Safety of Impella in Cardiogenic Shock Following Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

December 3, 2024 No Comments

This meta-analysis reviewed four randomized controlled trials (442 patients) to evaluate the use of Impella in managing cardiogenic shock (CS) following acute myocardial infarction (AMI). Impella reduced 6-month all-cause mortality (OR: 0.64, 95% CI: 0.43-0.95, P = .03) but showed no significant impact on 30-day mortality. However, Impella was linked to increased risks of major bleeding (OR: 3.61), limb ischemia (OR: 4.91), and sepsis (OR: 2.75). Future research is needed to balance survival benefits against these complications.

Comparing Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in Non-ST-Segment Elevation Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

November 29, 2024 No Comments

This systematic review and meta-analysis compared percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for treating non-ST-segment elevation acute coronary syndromes (NSTE-ACS). Analyzing data from 15 studies with 48,891 patients, results showed no significant mortality difference between PCI and CABG. However, CABG reduced the risk of myocardial infarction (RR = 0.56) and repeat revascularization (RR = 2.94), while PCI was associated with a lower risk of cerebrovascular accidents (RR = 0.58). These findings emphasize individualized treatment strategies based on patient-specific risk profiles.

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Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate Cardioplegia Solutions: An Animal Study With Prolonged Ischaemia

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

The Feasibility of Centralized Application Services for Perfusion Education Programs

Development and Validation of a Nomogram for Predicting Perioperative Transfusion in Children Undergoing Cardiac Surgery with CPB

The Incidence, Risk Factors, and Hospital Mortality of Prolonged Mechanical Ventilation Among Cardiac Surgery Patients: A Systematic Review and Meta-Analysis

A New Protocol for Removal of the Endothelium from the Perfused Rat Hind-Limb Preparation

Efficacy and Safety of Impella in Cardiogenic Shock Following Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

Comparing Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in Non-ST-Segment Elevation Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

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