CytoSorb Filter During Kidney Normothermic

Protocol for a Single-Centre Randomised Pilot Study to Assess the Safety and Feasibility of Adding a CytoSorb Filter During Kidney Normothermic Machine Perfusion to Remove Inflammatory and Immune Mediators Prior to Kidney Transplantation

April 3, 2025 No Comments

This pilot study assesses the safety and feasibility of using a CytoSorb filter during kidney normothermic machine perfusion (NMP) before transplantation. The goal is to reduce inflammation-related damage by filtering immune mediators. Twenty patients will be randomized to receive kidneys preserved with or without the filter. Outcomes include immune gene expression, delayed graft function, and kidney performance at intervals post-transplant.

Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate Cardioplegia Solutions: An Animal Study With Prolonged Ischaemia

April 3, 2025 No Comments

This study compares Del Nido (DN) and Bretschneider histidine-tryptophan-ketoglutarate (HTK) cardioplegia solutions in a porcine model of prolonged ischaemia. DN demonstrated superior left ventricular function, spontaneous return to sinus rhythm, and less haemodilution and endothelial dysfunction compared to HTK. Histological and biochemical markers of injury, stress, and apoptosis showed no significant differences, suggesting DN offers enhanced myocardial protection during cardiac surgery.

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

April 3, 2025 No Comments

This non-inferiority study evaluates the Quantum Perfusion System (QPS) for continuous blood gas monitoring during cardiopulmonary bypass (CPB) against the standard blood gas analyzer (BGA). Using data from 40 patients undergoing cardiac surgeries, QPS demonstrated high accuracy and agreement with BGA across all key parameters, adhering to Clinical Laboratory Improvement Amendments (CLIA) standards, and validating its utility as a trending device.

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

April 2, 2025 No Comments

The article explores the safety and effectiveness of the MANTA vascular closure device for managing large-bore arteriotomy, particularly post-decannulation in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients. Findings suggest the MANTA device reduces vascular complications and offers a viable, low-risk option for critically ill patients, though further high-powered studies are needed to confirm superiority over other closure methods.

A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

March 30, 2025 No Comments

This study compared six Health Canada-approved cardiopulmonary bypass (CPB) circuits in 872 cardiac surgery patients to assess their effects on bleeding and coagulation. While all circuits impaired coagulation, significant differences in bleeding severity and transfusion requirements were found after adjusting for patient and procedural factors. Circuit 6 showed the best performance in minimizing transfusion needs.

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

March 30, 2025 No Comments

This study compares two cardioplegic solutions—HTK and Del Nido—for their impact on cerebral inflammation in a porcine cardiopulmonary bypass model. Results showed that while both solutions produced comparable hypoxia and inflammation markers overall, HTK led to more pronounced hyponatremia, hypochloremia, and increased IL-1β mRNA in certain brain regions. Del Nido cardioplegia provided more stable electrolyte levels and less cerebral inflammation.

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

March 30, 2025 No Comments

This study presents the development of a novel optical CO₂ sensor for use in extracorporeal life support (ECLS) systems such as ECMO and ECCO₂R. The sensor accurately measures CO₂ concentration in oxygenator exhaust gas and gas flow to determine CO₂ removal rates. A built-in heating system prevents condensation, and a temperature control algorithm ensures measurement accuracy. Laboratory and in vivo validations confirm its clinical suitability.

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

March 29, 2025 No Comments

This retrospective study evaluates the safety and efficacy of innominate artery (IA) graft cannulation for selective antegrade cerebral perfusion (SACP) in aortic surgery. Analyzing 196 patients, including those with Type A acute aortic dissection and Marfan syndrome, the results showed low rates of stroke (2.04%), mortality (3.06%), and acute renal failure (3.06%). IA graft cannulation emerged as a reliable and efficient technique for cerebral protection during complex aortic procedures.

CytoSorb Hemoadsorption of Apixaban During Cardio-Pulmonary Bypass for Heart Transplantation

March 29, 2025 No Comments

This case study reports on the successful intraoperative removal of apixaban using a CytoSorb hemoadsorption device during emergency heart transplantation. The 61-year-old patient, previously on apixaban, underwent cardiopulmonary bypass (CPB), during which the device significantly reduced anticoagulant levels without complications. The results suggest CytoSorb may offer a viable method to manage DOACs in urgent cardiac surgery settings.

Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation During Cardiopulmonary Bypass

March 25, 2025 No Comments

This randomized clinical study assessed how varying sweep gas flow rates affect respiratory alkalosis and cerebral oxygenation during cardiopulmonary bypass (CPB) in 84 open-heart surgery patients. The findings revealed that lower sweep gas flow rates help maintain normal carbon dioxide levels and enhance cerebral oxygen saturation post-rewarming. Adjusting the sweep gas flow rate before rewarming may prevent complications associated with respiratory alkalosis.

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Protocol for a Single-Centre Randomised Pilot Study to Assess the Safety and Feasibility of Adding a CytoSorb Filter During Kidney Normothermic Machine Perfusion to Remove Inflammatory and Immune Mediators Prior to Kidney Transplantation

Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate Cardioplegia Solutions: An Animal Study With Prolonged Ischaemia

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

CytoSorb Hemoadsorption of Apixaban During Cardio-Pulmonary Bypass for Heart Transplantation

Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation During Cardiopulmonary Bypass

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