Near-Infrared Spectroscopy to Monitor Cerebral and Renal Oxygen Saturation During Cardiopulmonary Bypass Surgery

Near-Infrared Spectroscopy to Monitor Cerebral and Renal Oxygen Saturation During Cardiopulmonary Bypass Surgery for Paediatric Congenital Heart Disease: Study Protocol for a Prospective Observational Cohort Trial

This BMJ Open study outlines a prospective cohort trial evaluating near-infrared spectroscopy (NIRS) to monitor cerebral and renal oxygen saturation during pediatric cardiopulmonary bypass surgery. It aims to link intraoperative oxygenation levels with postoperative brain and kidney injuries, assessing outcomes with biomarkers and quality-of-life metrics. Findings could improve organ injury prediction and perioperative care in congenital heart disease surgeries.

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Evaluation of Postoperative Delirium

Evaluation of Postoperative Delirium in Cardiac Surgery Patients With the SDACS Screening Tool: A Multicenter-Multiphase Study

This study developed and validated the SDACS screening tool to predict postoperative delirium in cardiac surgery patients. Conducted across three academic hospitals with 920 participants, it identified four key predictors: chronic opioid use, hearing impairment, benzodiazepine history, and poor postoperative sleep. The tool demonstrated strong predictive power (AUC = 0.897), offering clinicians a practical instrument to guide early interventions.

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5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement

5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis

This study presents 5-year outcomes from the Evolut Low Risk trial, comparing transcatheter aortic valve replacement (TAVR) with surgery in low-risk patients with severe aortic stenosis. Results showed no significant difference in all-cause mortality or disabling stroke between the groups, affirming TAVR as a noninferior option. Both treatments maintained excellent valve performance, similar quality-of-life improvements, and low reintervention rates.

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Intraoperative Renal Near-Infrared Spectroscopy

Intraoperative Renal Near-Infrared Spectroscopy Monitoring as a Predictor of Renal Outcomes in Cardiac Surgery

This study assessed whether intraoperative renal near-infrared spectroscopy (NIRS) could predict acute renal failure (ARF) in 357 cardiac surgery patients. It found that longer durations of reduced renal oxygenation (rSO₂) below 80%, 70%, and 60% thresholds were significantly associated with ARF development. NIRS monitoring showed high sensitivity and specificity, indicating its potential for early detection and intervention during surgery.

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Impella Study

Multicentre Comparison of Various Microaxial Pump Devices as a Bridge to Durable Assist Device Implantation

This multicentre retrospective study evaluated the effectiveness of different microaxial flow pump (mAFP) devices—mainly Impella CP (3.5 L/min) and Impella 5+ (>5 L/min)—used to stabilize patients with severe heart failure before durable LVAD implantation. High-flow mAFPs were associated with improved hemodynamic support, reduced complications (e.g., renal/liver failure, RVAD use), and better mobilization, although 30-day mortality did not differ significantly between groups.

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CytoSorb Filter During Kidney Normothermic

Protocol for a Single-Centre Randomised Pilot Study to Assess the Safety and Feasibility of Adding a CytoSorb Filter During Kidney Normothermic Machine Perfusion to Remove Inflammatory and Immune Mediators Prior to Kidney Transplantation

This pilot study assesses the safety and feasibility of using a CytoSorb filter during kidney normothermic machine perfusion (NMP) before transplantation. The goal is to reduce inflammation-related damage by filtering immune mediators. Twenty patients will be randomized to receive kidneys preserved with or without the filter. Outcomes include immune gene expression, delayed graft function, and kidney performance at intervals post-transplant.

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Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate

Comparison of Del Nido and Histidine-Tryptophan-Ketoglutarate Cardioplegia Solutions: An Animal Study With Prolonged Ischaemia

This study compares Del Nido (DN) and Bretschneider histidine-tryptophan-ketoglutarate (HTK) cardioplegia solutions in a porcine model of prolonged ischaemia. DN demonstrated superior left ventricular function, spontaneous return to sinus rhythm, and less haemodilution and endothelial dysfunction compared to HTK. Histological and biochemical markers of injury, stress, and apoptosis showed no significant differences, suggesting DN offers enhanced myocardial protection during cardiac surgery.

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Quantum Perfusion

Real-Time Blood Gas Management: Evaluating Quantum Perfusion System’s Accuracy Against a Standard Blood Gas Analysis in CPB

This non-inferiority study evaluates the Quantum Perfusion System (QPS) for continuous blood gas monitoring during cardiopulmonary bypass (CPB) against the standard blood gas analyzer (BGA). Using data from 40 patients undergoing cardiac surgeries, QPS demonstrated high accuracy and agreement with BGA across all key parameters, adhering to Clinical Laboratory Improvement Amendments (CLIA) standards, and validating its utility as a trending device.

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Manta Ray

On MANTA Vascular Closure Devices Following Veno-Arterial Extracorporeal Membrane Oxygenation: Effectiveness and Complications

The article explores the safety and effectiveness of the MANTA vascular closure device for managing large-bore arteriotomy, particularly post-decannulation in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients. Findings suggest the MANTA device reduces vascular complications and offers a viable, low-risk option for critically ill patients, though further high-powered studies are needed to confirm superiority over other closure methods.

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A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

This study compared six Health Canada-approved cardiopulmonary bypass (CPB) circuits in 872 cardiac surgery patients to assess their effects on bleeding and coagulation. While all circuits impaired coagulation, significant differences in bleeding severity and transfusion requirements were found after adjusting for patient and procedural factors. Circuit 6 showed the best performance in minimizing transfusion needs.

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