The Novel St Thomas’ Hospital Polarizing Blood Cardioplegia: Results in Hearts With Reduced Ejection Fraction

July 13, 2025 No Comments

This study investigates the efficacy of a new St Thomas’ Hospital polarizing cardioplegia (STH-pol) versus standard depolarizing cardioplegia (STH-control) in rats with chronic myocardial infarction. Although STH-pol showed trends toward better coronary flow and reduced myocardial oxygen consumption, no statistically significant difference in myocardial protection was found. Both solutions demonstrated comparable recovery and energy preservation.

Patient Outcomes After Introduction of Novel Myocardial Protection Protocol for Prolonged Aortic Cross-Clamping

June 24, 2025 No Comments

This study evaluates the impact of a revised myocardial protection protocol implemented in 2021 at St. Marianna University School of Medicine for patients undergoing cardiac surgery with prolonged aortic cross-clamping (>4 hours). The revised protocol, focusing on the timing and method of blood cardioplegia administration, led to significantly lower postoperative creatine kinase levels and shorter hospital stays, indicating improved myocardial protection without altering the cardioplegia solution itself.

Minimally Invasive vs Conventional Coronary Bypass Surgery for Multivessel Coronary Disease

June 24, 2025 No Comments

This study compared minimally invasive coronary surgery (MICS-CABG) to traditional sternotomy-based CABG in patients with multivessel coronary artery disease. Analyzing matched cohorts of 244 patients each, the research found similar completeness of revascularization and comparable 5-year major adverse cardiac and cerebrovascular events (MACCE). MICS-CABG also had high graft patency (96.2%) and fewer transfusion needs, indicating it as a viable surgical alternative.

Neutrophil Percentage to Albumin Ratio Is Associated With In-Hospital Mortality in Patients With Acute Type A Aortic Dissection

June 5, 2025 No Comments

This study found that a higher neutrophil percentage to albumin ratio (NPAR) on hospital admission significantly predicts in-hospital mortality in patients undergoing surgery for acute type A aortic dissection (AAAD). Among 813 patients, higher NPAR levels correlated with increased risk of death, acute kidney injury, and longer ICU stays. NPAR outperformed neutrophils or albumin alone in prognostic value, suggesting it as a valuable, accessible clinical biomarker.

Evaluation of Intraoperative and Postoperative Blood Cell Salvage Use in Cardiac Surgery with Cardiopulmonary Bypass

June 3, 2025 No Comments

This study investigates the impact of using blood cell salvage (BCS) during and after cardiac surgery with cardiopulmonary bypass (CPB). Among 41 patients, those using BCS showed significantly improved hemoglobin and hematocrit levels, fewer red blood cell transfusions, lower infection rates, and shorter hospital stays. The findings support integrating BCS into Patient Blood Management strategies for better clinical outcomes.

Outcomes of a Standardized Protocol on the Management of Acute Type A Aortic Dissection: A Retrospective Cohort Study

May 15, 2025 No Comments

This retrospective study assessed a standardized surgical protocol implemented in 2016 for managing acute Type A aortic dissection (AAAD). Comparing pre- and post-protocol cohorts, the study found that standardized techniques improved consistency in surgical approach, reduced rates of aortic reoperations and dilations, and introduced safer cannulation and perfusion strategies. Mortality rates remained statistically unchanged, but the protocol significantly enhanced surgical outcomes.

Clinical and Preclinical Evidence on a Novel Percutaneous Pulsatile Ventricular Assist Device (PulseCath): Protocol for a Scoping Review

May 13, 2025 No Comments

This protocol outlines a scoping review to explore the clinical and preclinical applications of PulseCath, a novel percutaneous pulsatile ventricular assist device. Designed to bridge the gap between intra-aortic balloon pumps and Impella systems, PulseCath offers intermediate support for patients with hemodynamic instability. The review will systematically evaluate its hemodynamic effects, pathophysiological basis, and safety profile.

Del Nido Cardioplegia in Adult Cardiac Surgery: A Narrative Review

May 13, 2025 No Comments

This review explores the use of Del Nido cardioplegia in adult cardiac surgery, originally developed for pediatric use. It outlines its composition, benefits over traditional blood cardioplegia, and its mechanism in protecting the myocardium from ischemia-reperfusion injury. The article compiles data showing its efficacy in reducing cross-clamp times, myocardial injury, and transfusion requirements, with comparable or improved clinical outcomes.

Revolutionizing Cardiovascular Interventions With Artificial Intelligence

May 5, 2025 No Comments

This editorial outlines how artificial intelligence (AI) is transforming cardiovascular interventions by enhancing procedural planning, democratizing medical expertise, and expediting device development. AI-driven tools improve diagnostic accuracy, support training via simulation, and enable the creation of digital twins for personalized treatment planning. The article emphasizes AI’s potential to foster global equity in healthcare access and improve patient outcomes.

Predictors of Prolonged Intensive Care Unit Stay and In-Hospital Mortality Following Cardiac Surgery: An Integrated Analysis from the PROCARD-ATI Study

April 27, 2025 No Comments

This study analyzed 130 adult cardiac surgery patients to identify perioperative predictors of prolonged ICU stays and in-hospital mortality. Results revealed aortic cross-clamp time (AXCT) as the sole independent predictor of ICU stays ≥7 days, with a threshold of 110 minutes. For mortality, prolonged cardiopulmonary bypass time (CPBT), emergency surgery, and higher AXCT were key predictors. The findings suggest practical intraoperative benchmarks to enhance surgical strategies and outcomes.

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The Novel St Thomas’ Hospital Polarizing Blood Cardioplegia: Results in Hearts With Reduced Ejection Fraction

Patient Outcomes After Introduction of Novel Myocardial Protection Protocol for Prolonged Aortic Cross-Clamping

Minimally Invasive vs Conventional Coronary Bypass Surgery for Multivessel Coronary Disease

Neutrophil Percentage to Albumin Ratio Is Associated With In-Hospital Mortality in Patients With Acute Type A Aortic Dissection

Evaluation of Intraoperative and Postoperative Blood Cell Salvage Use in Cardiac Surgery with Cardiopulmonary Bypass

Outcomes of a Standardized Protocol on the Management of Acute Type A Aortic Dissection: A Retrospective Cohort Study

Clinical and Preclinical Evidence on a Novel Percutaneous Pulsatile Ventricular Assist Device (PulseCath): Protocol for a Scoping Review

Del Nido Cardioplegia in Adult Cardiac Surgery: A Narrative Review

Revolutionizing Cardiovascular Interventions With Artificial Intelligence

Predictors of Prolonged Intensive Care Unit Stay and In-Hospital Mortality Following Cardiac Surgery: An Integrated Analysis from the PROCARD-ATI Study

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