Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass

May 2, 2024 No Comments

This study investigates the effects of dexmedetomidine (Dex) pretreatment in patients undergoing cardiac valve replacement under cardiopulmonary bypass. In the Dex group, the time to the first rescue dose of propofol was longer, and the total propofol dosage was less than in the control group. Additionally, the Dex group showed reduced cardiac injury markers and inflammation, requiring less mechanical ventilation time than the control group. The findings suggest that Dex pretreatment offers myocardial protection and optimizes postoperative outcomes.

Intraoperative Goal-Directed Perfusion in Cardiac Surgery with Cardiopulmonary Bypass: The Roles of Delivery Oxygen Index and Cardiac Index

April 30, 2024 No Comments

This study explores the efficacy of intraoperative Goal-Directed Perfusion (GDP) in reducing postoperative complications, ICU, and hospital stay durations in cardiac surgery using cardiopulmonary bypass. By monitoring and optimizing oxygen delivery and cardiac index, GDP significantly lowered ICU stays and hospital lengths of stay, although it did not significantly affect mortality rates.

Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection

April 29, 2024 No Comments

Background and objectives: The relationship between cerebral perfusion and new postoperative ischemic stroke in obese patients is not well defined. The aim of this study

Evolution of Distal Limb Perfusion Management in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation with Femoral Artery Cannulation

April 23, 2024 No Comments

This narrative review explores the advancements in managing distal limb perfusion in venoarterial extracorporeal membrane oxygenation (VA ECMO) with femoral artery cannulation. Initially, no specialized techniques like distal perfusion cannulae were used, leading to limb ischemia. Recent innovations include prophylactic measures, various cannulation methods, and improved venous drainage techniques to enhance limb perfusion and reduce ischemic complications. Advanced monitoring tools like near-infrared spectroscopy aid in decision-making and management.

What is Perfusion?

April 17, 2024 No Comments

Perfusionists are integral healthcare professionals who operate devices like cardiopulmonary bypass machines during surgeries, especially open-heart operations. These experts manage the artificial blood pumps that maintain circulation, temporarily replacing the heart’s function. They also assemble and manage extracorporeal circulation (ECC) systems which support organ functions outside the body using devices like oxygenators and hemodialysis units. Perfusionists are vital in surgeries for diseases like coronary artery disease, heart failure, and during transplant operations, ensuring the continuation of life-supporting functions.

Advancing Cardiotomy Suction Practices for Coronary Surgery via Multidisciplinary Collaborative Learning

April 12, 2024 No Comments

This study focuses on a multidisciplinary quality-improvement intervention to standardize cardiotomy suction practices at the end of cardiopulmonary bypass during coronary artery bypass grafting. Conducted across 32 centers, the initiative showed significant improvements in adherence to recommended practices in Michigan centers compared to non-participating centers, with no adverse effects on clinical outcomes.

Examining Online International Health Professions Education: A Mixed Methods Review of Barriers, Facilitators, and Early Outcomes

April 7, 2024 No Comments

This study explores the feasibility and effectiveness of delivering Cardiovascular Perfusion education online to international students. Through mixed methods, barriers and facilitators to online health professions education were identified, informing the development of a novel online Extracorporeal Science (ECS) program. The first semester’s outcomes showed no significant difference in student performance or satisfaction compared to traditional in-person programs, highlighting the potential of online education to equalize access to healthcare education globally. The findings suggest that, with careful planning and incorporation of student feedback, online international education can achieve outcomes comparable to those of conventional programs.

Effectiveness of Dexmedetomidine as Myocardial Protector in Children With Classic Tetralogy of Fallot Having Corrective Surgery: A Randomized Controlled Trial

April 1, 2024 No Comments

This randomized controlled trial investigated dexmedetomidine’s (DEX) efficacy as a cardioprotective agent in children with classic tetralogy of Fallot undergoing corrective surgery in Indonesia. Administering DEX in the cardiopulmonary bypass solution significantly reduced troponin I levels, interleukin-6, and lactate levels postoperatively, indicating reduced cardiac injury and inflammation. It also improved cardiac output and reduced the need for vasoactive drugs in intensive care, although it did not significantly impact ventilation duration, ICU stay, or mortality. These findings suggest DEX is an effective cardioprotective agent in pediatric cardiac surgery.

Cerebral Protection in Acute Type A Aortic Dissection Surgery: A Comprehensive Systematic Review and Meta-Analysis

March 26, 2024 No Comments

This systematic review and meta-analysis aimed to compare antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP) methods for reducing cerebrovascular events during acute type A aortic dissection (ATAAD) surgeries. After assessing 26 studies involving 13,039 patients, findings suggest both ACP and RCP are safe and acceptable for emergency use. While no significant differences in permanent neurological dysfunction (PND) and mortality were observed between unilateral ACP (uACP) and bilateral ACP (bACP), uACP showed a preference in reducing transient neurologic deficits (TND). This study underscores the effectiveness of cerebral perfusion techniques in ATAAD surgery, highlighting uACP as a preferable method for minimizing TND.

Cerebral Perfusion and Metabolism with Mild Hypercapnia vs. Normocapnia in Porcine Models Post Cardiac Arrest: Impacts of Targeted Temperature Management

March 22, 2024 No Comments

This study evaluates the effects of mild hypercapnia compared to normocapnia on cerebral blood flow and metabolism in porcine models post-cardiac arrest, with and without targeted temperature management (TTM33). It involved resuscitating 39 pigs after 10 minutes of cardiac arrest and randomizing them to different conditions. Results indicate that hypercapnia increases cerebral flow in all groups, but raises intracranial pressure and lowers cerebral perfusion pressure in non-TTM animals. Hypercapnia with TTM33 showed reduced cerebral lactate, pyruvate, glycerol, and lactate/pyruvate ratios, highlighting the varying impacts of hypercapnia with TTM.

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Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass

Intraoperative Goal-Directed Perfusion in Cardiac Surgery with Cardiopulmonary Bypass: The Roles of Delivery Oxygen Index and Cardiac Index

Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection

Evolution of Distal Limb Perfusion Management in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation with Femoral Artery Cannulation

What is Perfusion?

Advancing Cardiotomy Suction Practices for Coronary Surgery via Multidisciplinary Collaborative Learning

Examining Online International Health Professions Education: A Mixed Methods Review of Barriers, Facilitators, and Early Outcomes

Effectiveness of Dexmedetomidine as Myocardial Protector in Children With Classic Tetralogy of Fallot Having Corrective Surgery: A Randomized Controlled Trial

Cerebral Protection in Acute Type A Aortic Dissection Surgery: A Comprehensive Systematic Review and Meta-Analysis

Cerebral Perfusion and Metabolism with Mild Hypercapnia vs. Normocapnia in Porcine Models Post Cardiac Arrest: Impacts of Targeted Temperature Management

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