Efficacy and Safety of Impella in Cardiogenic Shock Following Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

December 3, 2024 No Comments

This meta-analysis reviewed four randomized controlled trials (442 patients) to evaluate the use of Impella in managing cardiogenic shock (CS) following acute myocardial infarction (AMI). Impella reduced 6-month all-cause mortality (OR: 0.64, 95% CI: 0.43-0.95, P = .03) but showed no significant impact on 30-day mortality. However, Impella was linked to increased risks of major bleeding (OR: 3.61), limb ischemia (OR: 4.91), and sepsis (OR: 2.75). Future research is needed to balance survival benefits against these complications.

“Awake” Cannulation of Patients for Venovenous Extracorporeal Membrane Oxygenation: An Analysis of the Extracorporeal Life Support Organization Registry

November 24, 2024 No Comments

This study analyzed the outcomes of “awake” cannulation, where patients remain breathing spontaneously during venovenous ECMO cannulation, using data from over 28,000 patients. Only 2.8% underwent awake cannulation, which was associated with similar survival rates to mechanical ventilation cannulation after propensity score matching. Awake cannulation, increasingly utilized over time, shows potential for reducing ventilator-related lung injury but requires further research to identify optimal patient cohorts.

Cerebral Overperfusion Despite Reduced Cortical Metabolism Is Linked to Postoperative Delirium in Cardiac Surgery Patients

November 17, 2024 No Comments

This study explores the association between cerebral overperfusion and postoperative delirium (POD) in cardiac surgery patients. Continuous monitoring of cerebral blood flow, oxygen levels, and brain activity revealed increased middle cerebral artery velocity (MCAV) in patients with POD, despite stable oxygen saturation and autoregulation. The findings suggest that impaired cortical metabolism may render the brain vulnerable to overperfusion during surgery, increasing POD risk.

PerfusionGPT: AI-Powered Chatbot for Cardiac Surgery Professionals

November 16, 2024 No Comments

PerfusionGPT is an AI-powered chatbot based on ChatGPT-4, specifically designed to provide expert knowledge for perfusionists in cardiac surgery. It serves as a critical resource for both clinical decision-making and educational purposes in the field of perfusion.

Efficacy of Adjunct Hemoperfusion Compared to Standard Medical Therapy on 28-Day Mortality in Leptospirosis Patients with Renal Failure and Shock: A Single-Center Randomized Controlled Trial

September 29, 2024 No Comments

This study evaluates the impact of hemoperfusion (HP) on 28-day mortality in leptospirosis patients with renal failure and septic shock. A total of 37 patients were randomized to receive either standard medical therapy (SMT) or SMT with HP. The HP group showed a 36.84% risk reduction in 28-day mortality and significant improvements in inflammatory markers, renal function, and pulmonary function. Hemoperfusion was shown to be a safe and effective adjunct therapy, promoting faster recovery and increased survival rates.

Brain Death Donors on Extracorporeal Membrane Oxygenation Support

September 1, 2024 No Comments

This study examines 15 brain death donors on extracorporeal membrane oxygenation (ECMO) support, admitted to a specialized intensive care unit between 2018 and 2023. The study evaluates the effect of a strict hemodynamic monitoring schedule during a 6-hour observation period on the utilization rate of organs. Results show an increase in utilization rates from 78% to 88% with no significant differences in donor characteristics or hemodynamic data between periods. Most donors required multiple vasoactive drugs to maintain adequate perfusion.

Intraoperative Haemoadsorption for Antithrombotic Drug Removal During Cardiac Surgery: Initial Report of the International Safe and Timely Antithrombotic Removal (STAR) Registry

August 20, 2024 No Comments

This study investigates the monocyte-to-lymphocyte multiplying platelets ratio (MLPR) as a novel inflammatory marker for predicting acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Through analysis of 2387 patients, the study found that both MLPR and monocyte-to-lymphocyte ratio (MLR) were significant risk factors for AKI. MLPR displayed a J-shaped curve in relation to AKI, indicating its potential as a useful clinical tool for early AKI detection in cardiac surgery patients.

Standard Versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release

August 8, 2024 No Comments

This study aimed to compare the release of brain injury biomarkers between standard and high cardiopulmonary bypass (CPB) flow rates during elective cardiac surgery. Conducted at Sahlgrenska University Hospital in Sweden, forty patients were randomly assigned to either a standard (2.4 L/min/m²) or high (2.9 L/min/m²) CPB flow rate. The results indicated no significant differences in biomarker levels or the occurrence of postoperative delirium between the two groups. Age and sex were among factors associated with biomarker levels.

Global Perfusion Practice Survey: Readiness of On-Call and Emergency Operation Rooms

August 5, 2024 No Comments

This survey examines the readiness of on-call and emergency operation rooms for perfusion-related procedures during urgent situations in cardiac surgery. Data from 236 healthcare professionals highlight varied preferences for circuit readiness, influenced by caseload, response times, and other factors. The study underscores the need for standardized protocols to enhance perfusion safety and improve patient care.

Impact of Extracorporeal Haemoadsorption During Prolonged Cardiopulmonary Bypass on the Incidence of Acute Kidney Injury

June 26, 2024 No Comments

This study investigates the effects of haemoadsorption (HA) therapy on inflammatory markers and renal damage indices during cardiopulmonary bypass (CPB) and the early postoperative period. Conducted at a single tertiary care center, the retrospective analysis compared three groups of patients who underwent CPB for over 120 minutes. The results showed that haemoadsorption therapy did not significantly reduce the incidence of acute kidney injury (AKI) but decreased the need for renal replacement therapy.

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Efficacy and Safety of Impella in Cardiogenic Shock Following Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

“Awake” Cannulation of Patients for Venovenous Extracorporeal Membrane Oxygenation: An Analysis of the Extracorporeal Life Support Organization Registry

Cerebral Overperfusion Despite Reduced Cortical Metabolism Is Linked to Postoperative Delirium in Cardiac Surgery Patients

PerfusionGPT: AI-Powered Chatbot for Cardiac Surgery Professionals

Efficacy of Adjunct Hemoperfusion Compared to Standard Medical Therapy on 28-Day Mortality in Leptospirosis Patients with Renal Failure and Shock: A Single-Center Randomized Controlled Trial

Brain Death Donors on Extracorporeal Membrane Oxygenation Support

Intraoperative Haemoadsorption for Antithrombotic Drug Removal During Cardiac Surgery: Initial Report of the International Safe and Timely Antithrombotic Removal (STAR) Registry

Standard Versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release

Global Perfusion Practice Survey: Readiness of On-Call and Emergency Operation Rooms

Impact of Extracorporeal Haemoadsorption During Prolonged Cardiopulmonary Bypass on the Incidence of Acute Kidney Injury

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