Outcomes of Donation After Circulatory Death Heart Transplantation Using Normothermic Regional Perfusion

This study examines outcomes of donation after circulatory death (DCD) heart transplantation using thoracoabdominal normothermic regional perfusion (TA-NRP). A retrospective analysis of 32 recipients between 2020-2023 found 100% one-year survival, low rejection rates, and acceptable primary graft dysfunction (PGD) and cardiac allograft vasculopathy (CAV) rates. No significant differences were observed between co-localized and distant donor transplants. TA-NRP proves to be a viable method for DCD heart transplantation.

March 19, 2025

Buckberg vs. Del Nido in Isolated Aortic Valve Replacement: A Prospective, Two-Center, Randomized Trial

This study compares Buckberg (BS) and Del Nido (DNS) cardioplegia in isolated aortic valve replacement (AVR) through a two-center randomized trial with 311 patients. While postoperative creatine kinase and troponin levels showed no significant differences, the DNS group had better intraoperative glycemic control, higher spontaneous rhythm rates, and fewer cases of ventricular fibrillation requiring defibrillation. The study supports DNS as a viable alternative with workflow advantages.

March 16, 2025

The Feasibility of Centralized Application Services for Perfusion Education Programs

Perfusion education programs have grown significantly in the U.S. over the past 30 years, with increasing accreditation and student enrollment. This study explores the benefits of a centralized application service (CAS) for perfusion programs, highlighting cost reductions and streamlined admissions. With rising demand for perfusionists, a CAS could improve accessibility, efficiency, and applicant diversity, ultimately strengthening the profession’s future.

March 13, 2025

Limiting the Gamble: Risk and Predictability for Renal Replacement Therapy in Patients Receiving Mechanical Circulatory Support

This study investigates risk factors for renal replacement therapy (RRT) in patients receiving mechanical circulatory support (MCS). A retrospective analysis of 129 patients revealed an RRT incidence of 36%. Key risk factors include prior immunologic therapy and the presence of pacemakers or internal cardiac defibrillators. Unfractionated heparin showed minimal protection against RRT. Findings suggest systemic inflammation plays a role, emphasizing the need for alternative anticoagulation strategies.

March 11, 2025

Evaluating the Need for Magnesium Administration Following Cardioplegic Arrest with Del Nido Cardioplegia Solution

This study evaluates whether magnesium administration is necessary following cardioplegic arrest with del Nido cardioplegia (dNC) solution at Cincinnati Children’s Hospital Medical Center (CCHMC). Analyzing serum magnesium levels in 100 patients, results showed hypermagnesemia in most cases. Given the potential risks of excessive magnesium, findings suggest eliminating routine post-cross-clamp magnesium administration in dNC settings.

March 11, 2025

The Feasibility of a National Matching Service for Perfusion Education Program Applicants

As the demand for perfusion education programs (PEPs) grows, many qualified applicants struggle to secure spots due to inconsistent admission processes. This study examines the potential benefits of implementing a national matching service (NMS) for PEP applicants, similar to medical residency matches. By standardizing timelines, eliminating unfair practices, and ensuring efficient applicant-program matching, an NMS could enhance the recruitment process and support the growing need for perfusionists.

March 10, 2025

Development and Validation of a Checklist for Cardiopulmonary Bypass

This study focuses on developing and validating a checklist for cardiopulmonary bypass (CPB) to enhance patient safety and reduce adverse events. Using the Delphi method, five expert perfusionists refined an initial 42-item checklist down to 41 crucial elements. The final checklist standardizes CPB procedures, ensuring systematic verification of equipment and protocols. The study highlights the importance of structured guidelines in improving surgical outcomes and preventing errors.

March 10, 2025

PerfusionGPT: The Ultimate AI-Powered Resource for Perfusionists

PerfusionGPT is an AI-powered chatbot based on Open-AI’s latest models, specifically designed to provide expert knowledge for perfusionists in cardiac surgery. It serves as a critical resource for both clinical decision-making and educational purposes in the field of perfusion.

March 8, 2025

Perfusion Instability During Hyperthermic Intraperitoneal Chemotherapy: The Utility of a Problem-solving Flowchart

This study examines perfusion instability (PI) during hyperthermic intraperitoneal chemotherapy (HIPEC), where maintaining proper flow and temperature is crucial. A retrospective review of 208 HIPEC cases found a 10.1% incidence of PI. A step-by-step problem-solving flowchart was implemented, significantly improving perfusion stability. The study concludes that structured interventions can mitigate PI, though further research is needed to refine perfusion techniques.

March 6, 2025

Vasoplegic Syndrome Following Bypass: A Comprehensive Review of Pathophysiology and Proposed Treatments

Vasoplegic syndrome (VS) is a severe circulatory condition occurring post-cardiopulmonary bypass (CPB), affecting up to 44% of high-risk patients with mortality rates reaching 50%. It is characterized by profound hypotension, vasopressor resistance, and vascular collapse. The review explores pathophysiology, risk factors, and treatments, including nitric oxide synthase inhibitors (methylene blue, hydroxocobalamin), vasopressors, and fluid management to mitigate complications and improve survival.

March 1, 2025

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Category: Perfusion

Outcomes of Donation After Circulatory Death Heart Transplantation Using Normothermic Regional Perfusion

Buckberg vs. Del Nido in Isolated Aortic Valve Replacement: A Prospective, Two-Center, Randomized Trial

The Feasibility of Centralized Application Services for Perfusion Education Programs

Limiting the Gamble: Risk and Predictability for Renal Replacement Therapy in Patients Receiving Mechanical Circulatory Support

Evaluating the Need for Magnesium Administration Following Cardioplegic Arrest with Del Nido Cardioplegia Solution

The Feasibility of a National Matching Service for Perfusion Education Program Applicants

Development and Validation of a Checklist for Cardiopulmonary Bypass

PerfusionGPT: The Ultimate AI-Powered Resource for Perfusionists

Perfusion Instability During Hyperthermic Intraperitoneal Chemotherapy: The Utility of a Problem-solving Flowchart

Vasoplegic Syndrome Following Bypass: A Comprehensive Review of Pathophysiology and Proposed Treatments

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