Explore articles, research, and perspectives from the International Perfusion Association.
A systematic review of 31 studies examines cell and extracellular-vesicle therapies during organ perfusion, highlighting the gap between biomarkers and transplant function.
A 23-month-old donor supported on VA-ECMO provided a liver recovered using normothermic regional perfusion. The graft went to a child with maple syrup urine
In a 30-patient randomized pilot study, higher cardiac index combined with pulsatile bypass increased oxygen delivery and was associated with lower lactate. Small sample
In a randomized trial of 60 valve-surgery patients, adenosine added to terminal warm-blood aortic root reperfusion was associated with more intraoperative defibrillation and antiarrhythmic
An updated review of 20 observational studies links normothermic regional perfusion to fewer ischemic biliary complications after controlled DCD liver transplantation. Ischemic cholangiopathy risk
The X-COPD trial tested extracorporeal CO2 removal in COPD patients requiring invasive ventilation. Recruitment stopped at 18 of 192 planned patients. Ventilation duration was
A retrospective review of 75 abdominal NRP procedures compared intra-abdominal with descending thoracic cannulation. Thoracic access was associated with shorter cannulation time, higher circuit
A multicenter randomized trial analyzed 129 adults undergoing elective cardiac surgery to compare pulsatile and non-pulsatile bypass. Neither flow mode significantly changed peak inflammatory
Normothermic regional perfusion (NRP) can increase utilization of organs donated after circulatory death, but implementation varies across U.S. organ procurement organizations (OPOs). Interviews with
A study of 2,083 patients undergoing CABG found that 11.6% required prolonged mechanical ventilation for more than 48 hours. Researchers developed a simple preoperative
This retrospective study compared blood-based versus crystalloid cardiopulmonary bypass priming in 92 patients undergoing HeartMate 3 LVAD implantation. Blood-based priming was associated with significantly
This case report describes the first known heart-liver-kidney transplant for AL amyloidosis using organs recovered from a donation-after-circulatory-death donor with thoracoabdominal normothermic regional perfusion.
