Heart-Liver-Kidney Transplantation for AL Amyloidosis Using Normothermic Recovery and Storage From a Donor Following Circulatory Death: Short-Term Outcome in a First-in-World Experience

April 8, 2026 No Comments

This case report describes the first known heart-liver-kidney transplant for AL amyloidosis using organs recovered from a donation-after-circulatory-death donor with thoracoabdominal normothermic regional perfusion. A 40-year-old man with terminal multiorgan AL amyloidosis underwent sequential heart, liver, and kidney transplantation and remained free of graft dysfunction or rejection at 8 months, highlighting a new path to expand complex transplant access.

Protecting Red Blood Cells During Liver Machine Perfusion

Reduction in Red Blood Cell Lysis by Polymer Intervention During Rodent Liver Normothermic Machine Perfusion

March 25, 2026 No Comments

This preclinical rodent liver study tested whether Poloxamer 188 and Ficoll PM70 could reduce red blood cell hemolysis during normothermic machine perfusion. Both polymers lowered free hemoglobin and improved preservation of liver sinusoidal endothelial cells in donation after brain death and warm ischemia models. However, they did not significantly improve major perfusion metrics, and P188 showed a possible proinflammatory cytokine signal that warrants further study.

Normothermic Regional Perfusion, Organ Transplantation, Donation After Circulatory Death, Bibliometric Analysis, Graft Survival, Ischemia Reperfusion Injury, Heart Transplantation, Liver Transplantation, Kidney Transplantation, Transplant Outcomes

Normothermic Regional Perfusion in Organ Transplantation: Trends, Key Topics, and Evolving Research Focus

March 20, 2026 No Comments

This bibliometric analysis reviews 372 studies on normothermic regional perfusion (NRP) from 2014–2025, showing rapid growth in research and global adoption. The United States led in publications, while the United Kingdom led in citations. Research focus has shifted from kidney and liver complications to heart transplantation and outcomes, highlighting NRP’s expanding role in improving graft viability and transplant success.

Expanding the Donor Pool: Rethinking Time to Death in DCD Liver Transplantation

Donor Time to Death and DCD Liver Transplant Outcomes: Challenging the Dogma That Shorter Is Better

February 23, 2026 No Comments

This large UNOS registry study of 8,489 DCD liver transplants (2010–2024) found that shorter donor time to death (TTD) was associated with worse graft survival, while prolonged TTD did not negatively impact outcomes—even without normothermic regional perfusion (NRP). Despite this, liver utilization declined sharply after 15 minutes of TTD. Simulation modeling showed that avoiding TTD-based decline could increase utilization by 17%, potentially adding hundreds of safe transplants.

Elective Use of Intraoperative Extracorporeal Membrane Oxygenation in Patients With Pulmonary Fibrosis Reduces Primary Graft Dysfunction After Bilateral Lung Transplantation

February 23, 2026 No Comments

This single-center retrospective study evaluated 422 pulmonary fibrosis patients undergoing bilateral lung transplantation between 2012 and 2025. After adopting a more liberal elective intraoperative veno-arterial ECMO strategy in 2020, the incidence of severe primary graft dysfunction (PGD grade 3 at 72 hours) significantly decreased. Elective ECMO use was associated with shorter ventilation times, reduced dialysis rates, and a trend toward improved one-year graft survival without increasing major vascular complications.