International Perfusion Association

Category: ECMO

ECMO Team

Psychological Safety in an ECMO Retrieval Team: A Qualitative Study to Inform Improvement

This study explores psychological safety within an ECMO retrieval team at the Royal Brompton Hospital in London. By conducting semistructured interviews with consultants, nurses, and perfusionists, researchers identified factors influencing psychological safety. Key findings include the impact of the high-risk environment, structured team processes, and leadership behaviors on team communication and collaboration. Recommendations were made to enhance psychological safety by addressing these factors.

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Hospital Readmissions in Patients Supported with Durable Centrifugal-Flow Left Ventricular Assist Devices

The study examines hospital readmissions in patients with centrifugal-flow left ventricular assist devices (CF-LVADs), highlighting the commonality and impact on patient outcomes. Analyzing data from 204 patients, 67.7% experienced heart failure (HF)/LVAD-related readmissions, mainly due to major bleeding, infection, HF exacerbation, and neurological dysfunction. Using machine learning models, several pre-, intra-, and post-operative factors were identified as predictors of readmission risk, which can guide strategies to improve patient management and outcomes.

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Complications During Veno-Venous Extracorporeal Membrane Oxygenation in COVID-19 and Non-COVID-19 Patients with Acute Respiratory Distress Syndrome

This study compares complications in COVID-19 and non-COVID-19 patients with acute respiratory distress syndrome (ARDS) undergoing veno-venous extracorporeal membrane oxygenation (vv-ECMO). Retrospective analysis of 64 patients from March 2020 to March 2022 revealed higher pre-cannulation pneumothorax rates in COVID-19 patients. However, post-cannulation complications and clinical outcomes were similar between groups. Non-survivors showed a trend towards higher post-vv-ECMO complications.

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ECPR

Bleeding and Thrombosis in Patients With Out-of-Hospital Ventricular Tachycardia/Ventricular Fibrillation Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation

This study examines the incidence and predictors of bleeding and thrombosis in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR) after out-of-hospital cardiac arrest due to ventricular tachycardia/fibrillation. Among 200 patients, 67.5% experienced major bleeding, primarily from CPR-related trauma. Decreased fibrinogen levels were linked to bleeding, but bleeding did not significantly affect in-hospital mortality. Thrombosis occurred in 23.5% of patients and was not associated with in-hospital death.

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ECMO Kidney

Long-Term Clinical Outcomes of Acute Kidney Disease in Patients Receiving Extracorporeal Membrane Oxygenation

This study investigates the long-term outcomes of acute kidney disease (AKD) in patients undergoing extracorporeal membrane oxygenation (ECMO). From a dataset of 395 patients, 40.5% developed AKD. Those with AKD had a higher risk of major adverse kidney events (MAKEs) and cardiovascular events (MACEs). The risk of readmissions due to infections or sepsis was also elevated in AKD survivors, emphasizing the long-term impact of AKD in ECMO patients.

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Myocardial Protection

Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass

This study investigates the effects of dexmedetomidine (Dex) pretreatment in patients undergoing cardiac valve replacement under cardiopulmonary bypass. In the Dex group, the time to the first rescue dose of propofol was longer, and the total propofol dosage was less than in the control group. Additionally, the Dex group showed reduced cardiac injury markers and inflammation, requiring less mechanical ventilation time than the control group. The findings suggest that Dex pretreatment offers myocardial protection and optimizes postoperative outcomes.

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Duck Injection

Injection Site Matters: A Comparative Analysis of Transpulmonary Thermodilution via Simultaneous Femoral and Jugular Indicator Injections under Veno-Venous Extracorporeal Membrane Oxygenation Therapy

This study assesses how injection sites affect hemodynamic monitoring in patients on vv-ECMO therapy using the PiCCO system. By comparing simultaneous jugular and femoral indicator injections, it was found that femoral injections overestimate key parameters like EVLWI, ITBVI, and GEDVI. The discrepancies are linked to variations in the mean transit time and downslope time, correlated with extracorporeal blood flow, suggesting the injection site significantly impacts measurement accuracy.

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ECMO 45

Mid-Term Outcome after Extracorporeal Life Support in Postcardiotomy Cardiogenic Shock: Recovery and Quality of Life

This study evaluates the mid-term outcomes of extracorporeal life support (ECLS) in patients with refractory postcardiotomy cardiogenic shock, identifying factors like preoperative EuroSCORE II, renal function, cardiopulmonary bypass duration, and lactate levels as predictors of mortality. Survival rates and health-related quality of life (HRQoL) were assessed, showing acceptable results in surviving patients with a considerable percentage free from moderate to severe disability.

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DRESS

Heparin-Induced DRESS Syndrome in a Pediatric Patient and Successful Anaesthetic Management in Cardiovascular Bypass Surgery: Case Report

This case report discusses a pediatric patient with heparin-induced DRESS Syndrome managed successfully during cardiovascular bypass surgery. An 11-year-old with native aortic valve endocarditis developed DRESS after receiving unfractionated heparin. The syndrome, characterized by fever, eosinophilia, and a pruritic rash, was initially managed with corticosteroids. A subsequent episode prompted a shift to bivalirudin and fondaparinux, avoiding further complications and stabilizing the patient’s condition. This case emphasizes the need for alternative anticoagulation strategies in hypersensitive patients to improve outcomes.

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ECMO AI

Machine Learning Based Predictive Modeling of Readmissions Following Extracorporeal Membrane Oxygenation Hospitalizations

This study developed and assessed machine learning models, particularly using XGBoost, to predict 90-day nonelective readmissions following extracorporeal membrane oxygenation (ECMO) hospitalizations. Analyzing data from the Nationwide Readmissions Database (2016-2020), the study found that the XGBoost model outperformed traditional logistic regression in prediction accuracy and calibration. Key factors influencing readmission rates included duration of hospital stay, heart/lung transplants, and type of insurance.

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