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Category: ECMO

Extracorporeal Cardiopulmonary Resuscitation: Lifesaving for the Right Patient, at the Right Time and in the Right Place

Extracorporeal membrane oxygenation (ECMO), a life-saving technology for patients with cardiorespiratory failure unresponsive to standard treatments, has seen increased global use since the H1N1 pandemic in 2009, particularly for adult respiratory and cardiac failures. The most rapid expansion of its use has been in extracorporeal cardiopulmonary resuscitation (ECPR), which serves as a critical intervention in cases of refractory cardiac arrest, maintaining circulation and allowing time for potential reversal of the underlying cause.

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December 22, 2023

Meropenem Extraction by Ex Vivo Extracorporeal Life Support Circuits

The study investigates the impact of ECMO and CRRT circuits on meropenem pharmacokinetics, finding minimal extraction by ECMO components but rapid clearance during CRRT, indicating a need for adjusted meropenem dosing in critically ill patients on these therapies. Meropenem underwent significant degradation/metabolism in physiological conditions, informing clinicians on dosing strategies.

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December 22, 2023
ECMO CPT2

Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery

This study investigates the adsorption of propofol in extracorporeal membrane oxygenation (ECMO) circuits, noting that drugs prescribed to ECMO patients often lack optimized dosing strategies due to the circuit’s ability to adsorb drugs. It found that while only 27% of propofol was recovered after a bolus dose, more than 80% was recovered following a continuous infusion, suggesting direct dosing into ECMO circuits could mitigate altered drug exposure due to adsorption.

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December 21, 2023
Pediatric ECPR

ECPR for Prolonged Pediatric Cardiac Arrest, an Autcome Without Major Neurological Compromise

Pediatric in-hospital cardiac arrest (IHCA) occurs in 1-6% of pediatric ICU admissions, with survival rates improving from 9% to 35% over the past 25 years, partly due to the use of ECMO as a rescue strategy. A case is reported of a 4-month-old patient with ventricular and septal defects who underwent surgery, experienced complications leading to a prolonged cardiac arrest, and was successfully treated with ECMO.

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December 21, 2023

Building an Extracorporeal Cardiopulmonary Resuscitation Program at a High-volume Extracorporeal Membrane Oxygenation Center

The abstract discusses the establishment of an Extracorporeal Cardiopulmonary Resuscitation (ECPR) program in a high-volume extracorporeal membrane oxygenation (ECMO) center, emphasizing patient selection and outcome optimization. Despite lacking a 24/7 ECPR program, the center successfully evaluated and cannulated an in-hospital cardiac arrest patient during resuscitation, leading to survival, while an out-of-hospital cardiac arrest patient, considered a poor candidate for ECPR, did not survive despite ECMO center resources.

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December 20, 2023

A Multipurpose Extracorporeal Life Support Circuit: A Concept for Multiorgan Transplant and Circulatory Support Service Healthcare Provider

We propose the creation of a multipurpose circuit that integrates multiple extracorporeal life support (ECLS) functions to cater to diverse medical needs. This innovative circuit not only offers cost-effectiveness and enhanced safety but also ensures optimal utilization, thereby revolutionizing the realm of life support technologies.

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December 15, 2023
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