A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

March 30, 2025 No Comments

This study compared six Health Canada-approved cardiopulmonary bypass (CPB) circuits in 872 cardiac surgery patients to assess their effects on bleeding and coagulation. While all circuits impaired coagulation, significant differences in bleeding severity and transfusion requirements were found after adjusting for patient and procedural factors. Circuit 6 showed the best performance in minimizing transfusion needs.

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

March 30, 2025 No Comments

This study compares two cardioplegic solutions—HTK and Del Nido—for their impact on cerebral inflammation in a porcine cardiopulmonary bypass model. Results showed that while both solutions produced comparable hypoxia and inflammation markers overall, HTK led to more pronounced hyponatremia, hypochloremia, and increased IL-1β mRNA in certain brain regions. Del Nido cardioplegia provided more stable electrolyte levels and less cerebral inflammation.

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

March 30, 2025 No Comments

This study presents the development of a novel optical CO₂ sensor for use in extracorporeal life support (ECLS) systems such as ECMO and ECCO₂R. The sensor accurately measures CO₂ concentration in oxygenator exhaust gas and gas flow to determine CO₂ removal rates. A built-in heating system prevents condensation, and a temperature control algorithm ensures measurement accuracy. Laboratory and in vivo validations confirm its clinical suitability.

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

March 29, 2025 No Comments

This retrospective study evaluates the safety and efficacy of innominate artery (IA) graft cannulation for selective antegrade cerebral perfusion (SACP) in aortic surgery. Analyzing 196 patients, including those with Type A acute aortic dissection and Marfan syndrome, the results showed low rates of stroke (2.04%), mortality (3.06%), and acute renal failure (3.06%). IA graft cannulation emerged as a reliable and efficient technique for cerebral protection during complex aortic procedures.

Outcomes of Donation After Circulatory Death Heart Transplantation Using Normothermic Regional Perfusion

March 19, 2025 No Comments

This study examines outcomes of donation after circulatory death (DCD) heart transplantation using thoracoabdominal normothermic regional perfusion (TA-NRP). A retrospective analysis of 32 recipients between 2020-2023 found 100% one-year survival, low rejection rates, and acceptable primary graft dysfunction (PGD) and cardiac allograft vasculopathy (CAV) rates. No significant differences were observed between co-localized and distant donor transplants. TA-NRP proves to be a viable method for DCD heart transplantation.

Buckberg vs. Del Nido in Isolated Aortic Valve Replacement: A Prospective, Two-Center, Randomized Trial

March 16, 2025 No Comments

This study compares Buckberg (BS) and Del Nido (DNS) cardioplegia in isolated aortic valve replacement (AVR) through a two-center randomized trial with 311 patients. While postoperative creatine kinase and troponin levels showed no significant differences, the DNS group had better intraoperative glycemic control, higher spontaneous rhythm rates, and fewer cases of ventricular fibrillation requiring defibrillation. The study supports DNS as a viable alternative with workflow advantages.

The Feasibility of Centralized Application Services for Perfusion Education Programs

March 13, 2025 No Comments

Perfusion education programs have grown significantly in the U.S. over the past 30 years, with increasing accreditation and student enrollment. This study explores the benefits of a centralized application service (CAS) for perfusion programs, highlighting cost reductions and streamlined admissions. With rising demand for perfusionists, a CAS could improve accessibility, efficiency, and applicant diversity, ultimately strengthening the profession’s future.

Limiting the Gamble: Risk and Predictability for Renal Replacement Therapy in Patients Receiving Mechanical Circulatory Support

March 11, 2025 No Comments

This study investigates risk factors for renal replacement therapy (RRT) in patients receiving mechanical circulatory support (MCS). A retrospective analysis of 129 patients revealed an RRT incidence of 36%. Key risk factors include prior immunologic therapy and the presence of pacemakers or internal cardiac defibrillators. Unfractionated heparin showed minimal protection against RRT. Findings suggest systemic inflammation plays a role, emphasizing the need for alternative anticoagulation strategies.

Evaluating the Need for Magnesium Administration Following Cardioplegic Arrest with Del Nido Cardioplegia Solution

March 11, 2025 No Comments

This study evaluates whether magnesium administration is necessary following cardioplegic arrest with del Nido cardioplegia (dNC) solution at Cincinnati Children’s Hospital Medical Center (CCHMC). Analyzing serum magnesium levels in 100 patients, results showed hypermagnesemia in most cases. Given the potential risks of excessive magnesium, findings suggest eliminating routine post-cross-clamp magnesium administration in dNC settings.

The Feasibility of a National Matching Service for Perfusion Education Program Applicants

March 10, 2025 No Comments

As the demand for perfusion education programs (PEPs) grows, many qualified applicants struggle to secure spots due to inconsistent admission processes. This study examines the potential benefits of implementing a national matching service (NMS) for PEP applicants, similar to medical residency matches. By standardizing timelines, eliminating unfair practices, and ensuring efficient applicant-program matching, an NMS could enhance the recruitment process and support the growing need for perfusionists.

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A Clinical Comparison of the Effects of Six Disposable Cardiopulmonary Bypass Circuits on Bleeding and Coagulation: A Quality Assurance Project

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan–Ketoglutarate and Del Nido Cardioplegia

Development of a CO₂ Sensor for Extracorporeal Life Support Applications

Innominate Artery Graft Cannulation for Selective Antegrade Cerebral Perfusion in Aortic Surgery: Clinical Findings and Feasibility

Outcomes of Donation After Circulatory Death Heart Transplantation Using Normothermic Regional Perfusion

Buckberg vs. Del Nido in Isolated Aortic Valve Replacement: A Prospective, Two-Center, Randomized Trial

The Feasibility of Centralized Application Services for Perfusion Education Programs

Limiting the Gamble: Risk and Predictability for Renal Replacement Therapy in Patients Receiving Mechanical Circulatory Support

Evaluating the Need for Magnesium Administration Following Cardioplegic Arrest with Del Nido Cardioplegia Solution

The Feasibility of a National Matching Service for Perfusion Education Program Applicants

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