Conceptual illustration of lungs and extracorporeal CO2 removal for COPD

Extracorporeal CO2 Elimination for Acute Exacerbation of Severe COPD Requiring Invasive Mechanical Ventilation: A Randomized Controlled Trial (the X-COPD Trial)

October 7, 2026 No Comments

The X-COPD trial tested extracorporeal CO2 removal in COPD patients requiring invasive ventilation. Recruitment stopped at 18 of 192 planned patients. Ventilation duration was shorter with ECCO2R, but death or severe disability at day 60 was not significantly reduced. One ECCO2R patient had severe bleeding. The findings support further research into assisted early extubation, while the small sample, unblinded design, and early termination prevent firm conclusions about clinical benefit or safety.

A tablet displaying the actual iPerfusion.org homepage beside a globe, coffee, and a playful headset-wearing duck.

Same Mission, Better Circuit: Welcome to the New iPerfusion.org

October 7, 2026 No Comments

We’ve refreshed iPerfusion.org with cleaner pages, easier research browsing, clearer mission information, and the new PerfusionGPT chatbot. Here’s a look at what changed, what we’re still improving, and why we spent more time than expected talking about buttons.

AI-generated conceptual still-life of an anatomical torso model, perfusion cannulae, tubing, and a stopwatch.

Intra-Abdominal Versus Descending Thoracic Cannulation Techniques for Abdominal Normothermic Regional Perfusion

October 7, 2026 No Comments

A retrospective review of 75 abdominal NRP procedures compared intra-abdominal with descending thoracic cannulation. Thoracic access was associated with shorter cannulation time, higher circuit flows, and fewer red-cell transfusions. Larger lactate changes occurred during longer perfusion runs, but duration-normalized values were similar. Selection bias and concurrent thoracic organ recovery limit interpretation; organ utilization and recipient outcomes were not available.