Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury Requiring Dialysis After Cardiac Surgery: A Retrospective Study from the National Heart Institute of Malaysia

April 6, 2026 No Comments

This retrospective Malaysian cohort study examined 6,779 adult cardiac surgery patients and found that 4.5% developed postoperative acute kidney injury requiring dialysis. Risk was higher in patients with chronic kidney disease, urgent surgery, diabetes, reoperation, and longer ICU stay. Dialysis-requiring AKI was linked to sharply increased mortality, especially among patients without baseline CKD, highlighting the need for earlier renal risk stratification and kidney-protective perioperative care.

The Combined Use of HA380 Hemoperfusion in Cardiopulmonary Bypass Alleviates Postoperative Inflammatory Response and Organ Dysfunction Following Cardiac Surgery

April 6, 2026 No Comments

This randomized single-center trial evaluated 65 patients undergoing elective cardiac surgery with cardiopulmonary bypass and found that adding the HA380 hemoperfusion cartridge reduced early postoperative inflammatory cytokines, including IL-1β, IL-6, IL-8, and IL-10. The HA380 group also had lower vasoactive-inotropic requirements and better short-term liver and kidney laboratory markers, although ICU ventilation time and ICU stay were not significantly improved.