This nationwide cross-sectional study investigated the prevalence of musculoskeletal disorders (MSDs) among perfusionists working in German cardiac centers. Using the Nordic Musculoskeletal Questionnaire, researchers surveyed 287 professionals. Results showed that 86% reported MSD symptoms within the past year, most commonly in the lower back and neck. Increasing age and years of professional experience were associated with higher prevalence, highlighting the need for ergonomic improvements and occupational health strategies.