This article explores the transformative potential of artificial intelligence (AI) in cardiopulmonary bypass (CPB) and perfusion. AI enhances decision-making by analyzing patient data, optimizing blood flow and pressure parameters, and providing real-time alerts during surgery. It facilitates personalized care, streamlines routine tasks, and improves patient outcomes, particularly in high-risk groups. As AI evolves, it promises to redefine the role of perfusionists and elevate the standards of care in cardiac surgery.