This study evaluates the mid-term outcomes of extracorporeal life support (ECLS) in patients with refractory postcardiotomy cardiogenic shock, identifying factors like preoperative EuroSCORE II, renal function, cardiopulmonary bypass duration, and lactate levels as predictors of mortality. Survival rates and health-related quality of life (HRQoL) were assessed, showing acceptable results in surviving patients with a considerable percentage free from moderate to severe disability.