This study investigates the infusion of microparticles in CRRT circuits, identifying disposable components like tubing and bags as sources. It highlights the effective role of in-line filters in reducing these particles, demonstrating a decrease in microparticle concentration from 14 mg/mL to 11 mg/mL post-filter. The study suggests that using in-line filters can mitigate iatrogenic damage and improve patient outcomes during extracorporeal treatments in intensive care.