Protocol for Venoarterial Extracorporeal Membrane Oxygenation to Reduce Morbidity and Mortality Following Bilateral Lung Transplantation: The ECMOToP Randomised Controlled Trial
The ECMOToP trial aims to evaluate the effectiveness of two VA-ECMO initiation strategies in patients undergoing bilateral lung transplantation for obstructive or restrictive lung diseases. This multicentre randomised controlled trial contrasts an ‘on-demand’ approach, where VA-ECMO is initiated based on specific hemodynamic and respiratory needs, with a ‘systematic’ strategy of preemptive initiation. The primary endpoint is the number of ventilator-free days at day 28, with secondary endpoints including organ failure occurrence, vital status at day 28, day 90, and year 1, along with adverse events. This research endeavors to establish a more effective protocol for VA-ECMO initiation, potentially improving survival and quality of life for lung transplant recipients.
