This study compared minimally invasive aortic valve replacement (MIAVR) to conventional approaches (CAVR) in 203 obese patients, using propensity-matched analysis to ensure comparability. Results indicated no significant difference in 30-day mortality rates, with MIAVR patients benefiting from faster extubation times, reduced need for continuous positive airway pressure therapy, and shorter ICU stays, though hospital stays were comparable. This suggests that MIAVR is a safe, effective option for obese patients, offering notable postoperative respiratory and recovery advantages.